Cardiac Performance in Mechanically Ventilated COVID-19 Patients
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|ClinicalTrials.gov Identifier: NCT04628195|
Recruitment Status : Completed
First Posted : November 13, 2020
Last Update Posted : November 13, 2020
|Condition or disease|
|Covid19 Acute Cor Pulmonale Cardiac Failure|
|Study Type :||Observational|
|Actual Enrollment :||100 participants|
|Official Title:||Cardiac Performance in Mechanically Ventilated Patients With Severe Pneumonia by SARS-CoV-2: Echo-COVID Study|
|Actual Study Start Date :||April 1, 2020|
|Actual Primary Completion Date :||June 30, 2020|
|Actual Study Completion Date :||August 1, 2020|
- Percentage of patients with left ventricle dysfunction (hypokinetic) [ Time Frame: 3 month ]Hypokinetic left ventricle function (left ventricle ejection fraction <45%)
- Percentage of patients with acute cor pulmonale [ Time Frame: 3 month ]Acute cor pulmonale was defined as a dilated right ventricle (right ventricle end-diastolic area/left ventricle end-diastolic area ratio >0.6) associated with the presence of paradoxical septum motion
- Differences in respiratory system compliance between patients with and without acute cor pulmonale [ Time Frame: Within the first 24 hours of mechanical ventilation. ]Respiratory system compliance is defined as the change in lung volume (Tidal volume, ml) produced by a unit change in pulmonary pressure (driving pressure, cmH2O). The reported value of respiratory system compliance will be reported in ml/cmH2O.
- Differences in partial arterial pressure of carbon dioxide (PCO2) between patients with and without acute cor pulmonale [ Time Frame: Within the first 24 hours of mechanical ventilation. ]Partial arterial pressure of carbon dioxide will be reported in mmHg.
- Differences in PaO2/FiO2 ratio between patients with and without acute cor pulmonale [ Time Frame: Within the first 24 hours of mechanical ventilation. ]PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction). The reported value is a positive integer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04628195
|Pontificia Universidad Católica de Chile|
|Santiago, Región Metropolitana, Chile, 7550028|