Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome (LungMechCoV-19)
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|ClinicalTrials.gov Identifier: NCT04597853|
Recruitment Status : Not yet recruiting
First Posted : October 22, 2020
Last Update Posted : October 22, 2020
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies.
This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
|Condition or disease||Intervention/treatment|
|Covid19 ARDS||Diagnostic Test: Assessment of lung mechanics and heart-lung interactions|
|Study Type :||Observational|
|Estimated Enrollment :||25 participants|
|Official Title:||Assessment of Lung Mechanics in SARS-CoV-2/ COVID-19 Acute Respiratory Distress Syndrome: A Holistic, Longitudinal Analysis of the Lung-heart-ventilator Interaction|
|Estimated Study Start Date :||October 20, 2020|
|Estimated Primary Completion Date :||October 31, 2021|
|Estimated Study Completion Date :||December 31, 2021|
- Diagnostic Test: Assessment of lung mechanics and heart-lung interactions
Impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry and classic mechanical ventilation parameters
- Time dependent compliance change [ Time Frame: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days) ]Compliance change over the length of mechanical ventilation
- PEEP and time dependent change in dead space [ Time Frame: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days) ]Change in Dead Space over the length of mechanical ventilation
- PEEP and time dependent change in shunt fraction [ Time Frame: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days) ]Change in shunt fraction over the length of mechanical ventilation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04597853
|Contact: Philipp K Buehler, MD||+41 43 25 31340||Philipp.Buehler@usz.ch|