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EEG Responses to Arabic Music Scales

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04573101
Recruitment Status : Active, not recruiting
First Posted : October 5, 2020
Last Update Posted : April 27, 2022
Sponsor:
Information provided by (Responsible Party):
Weill Cornell Medical College in Qatar

Brief Summary:
Recent studies showed that various factors can contribute to the efficiency of a music therapy such as the type of music used, the type of instrument, the ethnicity, musical preference of the subjects and many others. Investigators noticed that most of studies and clinical trials, while acknowledging the importance of ethnicity and musical preferences, use the Western Music type in their investigations and practice. While in the Middle East, Music Therapy played a tremendous role in the 10th century since the "scales theory" of the famous Scientists El Farabi and Avicenna, very little countries of the Middle East are investing in scientific studies using Arabic Music as a therapeutic tool. This study will be an electroencephalogram (EEG)-based investigation on correlations of multiple factors that can influence the cortical responses of the subject to the music and self-reported state of emotion and anxiety.

Condition or disease Intervention/treatment Phase
Healthy Other: Music listening / EEG recording Not Applicable

Detailed Description:

This is the first clinical study involving Music in Qatar and the Gulf region, and the first study to explore Arab Music Scales using a combination of EEG and self-reported assessements.

Using EEG, investigators will analyze the full brain activity of brainwaves produced by up to 100 subjects in response to the audio musical stimuli. 24 different audio recordings have been designed to investigate on different acoustic cues:

  • with versus without quartertones
  • known music versus improvisation
  • Maqam Saba (sad) versus maqam Kurd (happy)
  • 3 different Middle Eastern instruments: Ney, Oud and Qanun
  • Two pitches: from Re or from Sol

The presentation of the audio stimuli clips will be randomized by the SuperLab5 software and EEG brainwaves will be recorded using the Power Lab (AD instrument). Between every audio clip, recording will be paused to ask the subjects to self-report on their emotional and anxiety states using a self-evaluation questionnaire. Subjects will be randomly assigned to morning of afternoon sessions of recording.

Using bioinformatic tools, investigators will perform a correlation study between EEG results, emotional self-report from the PANAS-X questionnaire, as well as answers to another questionnaire asking for their age, gender, ethnicity, right or left handedness, musical preferences, and if the subject plays an instrument.

The outcomes will have direct applications on the development of personalized Music Therapy in the region for treatment and management of mental health conditions, neurodegenerative diseases and other conditions that are of high prevalence in the region.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: Each participants is exposed to 24 different audio recordings and asked to select emotion that best describes feeling after each auditory stimulus. The 24 audio stimuli are distributed in a random manner by computer. In addition, emotional assessment is performed before and after the session. This is a total of 26 arms.
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: An EEG-based Exploration of the Variables Affecting Cortical Responses to Arabic Music Scales for a Personalised and Effective Music Therapy in the Middle East: a Clinical Study
Actual Study Start Date : February 11, 2019
Estimated Primary Completion Date : December 31, 2022
Estimated Study Completion Date : December 31, 2023

Arm Intervention/treatment
No Intervention: Before intervention
Participants answer questionnaire before any stimulus is given.
No Intervention: After intervention
Participants answer questionnaire after the series of stimulus is given.
Experimental: N1 (Ney - Improvisation- Saba Re)
Improvisation with Ney, on Saba maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O1 (Oud - Improvisation- Saba Re)
Improvisation with Oud, on Saba maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q1(Qanun - Improvisation- Saba Re)
Improvisation with Qanun, on Saba maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N2 (Ney - Improvisation- Saba Sol)
Improvisation with Ney, on Saba maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O2 (Oud - Improvisation- Saba Sol)
Improvisation with Oud, on Saba maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q2 (Qanun - Improvisation- Saba Sol)
Improvisation with Qanun, on Saba maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N3 (Ney - Improvisation- Kurd Re)
Improvisation with Ney, on Kurd maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O3 (Oud - Improvisation- Kurd Re)
Improvisation with Oud, on Kurd maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q3 (Qanun - Improvisation- Kurd Re)
Improvisation with Qanun, on Kurd maqam on Re.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N4 (Ney - Improvisation- Kurd Sol)
Improvisation with Ney, on Kurd maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O4 (Oud - Improvisation- Kurd Sol)
Improvisation with Oud, on Kurd maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q4 (Qanun - Improvisation- Kurd Sol)
Improvisation with Qanun, on Kurd maqam on Sol.
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N5 (Ney - Known music- Kurd Re)
Known music with Ney, on Kurd maqam on Re. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O5 (Oud - Known music- Kurd Re)
Known music with Oud, on Kurd maqam on Re. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q5 (Qanun - Known music- Kurd Re)
Known music with Qanun, on Kurd maqam on Re. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N6 (Ney - Known music- Kurd Sol)
Known music with Ney, on Kurd maqam on Sol. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O6 (Oud - Known music- Kurd Sol)
Known music with Oud, on Kurd maqam on Sol. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q6 (Qanun - Known music- Kurd Sol)
Known music with Qanun, on Kurd maqam on Sol. (El Rabii)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N7 (Ney - Known music- Saba Re)
Known music with Ney, on Saba maqam on Re. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O7 (Oud - Known music- Saba Re)
Known music with Oud, on Saba maqam on Re. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q7 (Qanun - Known music- Saba Re)
Known music with Qanun, on Saba maqam on Re. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: N8 (Ney - Known music- Saba Sol)
Known music with Ney, on Saba maqam on Sol. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: O8 (Oud - Known music- Saba Sol)
Known music with Oud, on Saba maqam on Sol. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf

Experimental: Q8 (Qanun - Known music- Saba Sol)
Known music with Qanun, on Saba maqam on Sol. (Howa Sahih)
Other: Music listening / EEG recording
Participants listen to 24 different audio clips of 1 min long each, and select emotion in between. EEG is recorded while participants are listening. Participants select the emotion that best describes their feeling from Table 1 of the PANAS-X. https://www2.psychology.uiowa.edu/faculty/clark/panas-x.pdf




Primary Outcome Measures :
  1. Quantification of brain waves [ Time Frame: During the intervention (an average of 30 minutes) ]
    Relative power of each of the brainwaves (alpha, beta, gamma, theta, delta).

  2. Quantification of selected emotions [ Time Frame: immediately before each intervention ]
    Count of every emotion (selected by participant from the provided Table).

  3. Quantification of selected emotions [ Time Frame: immediately after each intervention ]
    Count of every emotion (selected by participant from the provided Table)



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Age: 18 years old to or above (might include pregnant women)
  2. Living in Qatar
  3. Understand either English or arabic

Exclusion Criteria:

  1. Individuals not meeting the inclusion criteria
  2. Individuals with auditory impairments
  3. Individuals with any known neurological condition (including epilepsy, Alzheimer, Parkinson, Autism etc)
  4. Individuals not able to come to the site (WCMQ).
  5. Adults not able to consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04573101


Locations
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Qatar
Ghizlane Bendriss
Doha, Qatar, 24144
Sponsors and Collaborators
Weill Cornell Medical College in Qatar
Investigators
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Principal Investigator: GHIZLANE BENDRISS, PhD Weill Cornell Medicine Qatar
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Responsible Party: Weill Cornell Medical College in Qatar
ClinicalTrials.gov Identifier: NCT04573101    
Other Study ID Numbers: 19-00013
First Posted: October 5, 2020    Key Record Dates
Last Update Posted: April 27, 2022
Last Verified: April 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: Individual participants data that underlie the results reported will be available after deidentification beginning 3 months after publication and ending 3 years after publication. The study protocol and statistical analysis plan will also be available beginning 3 months after publication and ending 3 years after publication. Anyone who wishes to access the individual data, to achieve aims in the approved proposal, will be eligible to gain access to data by submitting a proposal to ghb2002@qatar-med.cornell.edu and data will be available at this link: https://drive.google.com/drive/folders/1OVjWK7RNTs18c4OIDQErzGjbhmUC98qi?usp=sharing
Supporting Materials: Study Protocol
Statistical Analysis Plan (SAP)
Time Frame: 3 month after publication and ending 3 years after publication.
Access Criteria: Send proposal to ghb2002@qatar-med.cornell.edu

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Weill Cornell Medical College in Qatar:
Music
Emotions
Ethnicity
Culture
Music Preference