Nutritional Habits, and Coronavirus Disease 2019 (COVID-19) Outcome
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT04447144|
Recruitment Status : Recruiting
First Posted : June 25, 2020
Last Update Posted : June 30, 2020
As of May 30th more than 23,000 cases of COVID -19 cases were confirmed in Egypt with total deaths of 913. Post viral entry, intense immune response against the virus with infiltration of monocytes and macrophages into alveolar cells with decreasing number of lymphocytes in peripheral blood along with reduced lymphocytes in lymphoid organs, hypercoagulability, thrombosis and multiple organ damage, The gut microbiota and immune homeostasis seem to have a back and forth relationship.
Also, gut microbiota derived signals are known to tune the immune cells for pro and anti-inflammatory responses thereby affecting the susceptibility to various diseases. Healthy gut microbiome essentially could be pivotal in maintaining an optimal immune system to prevent an array of excessive immune reactions that eventually become detrimental to lungs and vital organ systems.
Numerous studies have shown that the patient's nutritional status have a significant effect on an individual's immunity and over all health status and it has been suggested that nutritional deficiencies may predispose to severe forms of COVID-19 infections.
Co-existing non-communicable chronic diseases (NCDs) in COVID-19 patients have been found to delay patients recovery and worsen their prognosis, the reason may be due to aggravated inflammatory pathology found in NCDs exacerbating COVID-19 infection.
The aim of the study is to evaluate the role dietary habits among COVID-19 Egyptian patients and whether type of diet (Mediterranean or Western) will affect disease outcomes
|Condition or disease|
|Covid19 Chronic Inflammation Non-Communicable Chronic Diseases|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Nutritional Habits, Does it Affect Coronavirus Disease 2019 (COVID-19) Infection Outcome? An Egyptian Experience|
|Actual Study Start Date :||June 1, 2020|
|Estimated Primary Completion Date :||August 1, 2020|
|Estimated Study Completion Date :||September 1, 2020|
COVID-19 mild severity
Definition of mild cases according to MOH:
COVID-19 moderate severity
Any patient not fulfilling the above mild criteria is considered having moderate disease as well as any positive pulmonary imaging findings
- Western versus Mediterranean diet in COVID-19 outcome [ Time Frame: 2 months ]To assess the relation between type of diet in mild to moderate COVID 19, to the fate of their course; either improvement or progression
- Gut- Lung axis in COVID-19 [ Time Frame: 2 months ]To asses any possible links between gut microbiome and the lung affecting clinical presentation of mild to moderate COVID cases; as diarrhea, loss of taste or smell
- Protective role of minerals and vitamins in COVID-19 patients [ Time Frame: 2 months ]Possible protective effects of minerals and vitamins against COVID-19 respiratory illness
- non-communicable diseases and COVID-19 [ Time Frame: 2 months ]Trying to explain the link between non-communicable disease severity and COVID-19 prognosis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04447144
|Contact: Mona M Abd-Elmonem Hegazy, MD||+20 100 142 firstname.lastname@example.org|
|Contact: Ahmed M Abdul Ghani, MDemail@example.com|
|Study Director:||Ahmed M Abdul Ghani, MD||Lecture of Internal Medicine Hepatology & gastroenterology Unit|