Evaluation of ABO Isoagglutinins Level in Blood Group O Donors
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|ClinicalTrials.gov Identifier: NCT04412993|
Recruitment Status : Not yet recruiting
First Posted : June 2, 2020
Last Update Posted : June 2, 2020
|Condition or disease||Intervention/treatment|
|Isoagglutinins Level||Other: withdraw blood samples|
the use of O blood group transfusion to patients of all groups has continued since the second world war, nevertheless the transfusion of group O plasma/ platelet concentrate to group A, B and AB recipient sometimes causes severe red cell destruction , Acute haemolysis has been reported following transfusion of non-iso group single donor platelet (PLT) concentrates and may be more common than is appreciated.
This red blood cells destruction happens based on the fact that the sera from group O people contain two separable antibodies, anti-A and anti-B .
When it comes to PLT transfusion therapy we are dealing with issues arising from the fact that PLTs contain both significant amounts of ABO antigen on their surface, as well as anti ABO isogglutinins in the donor's plasma which caused reduction the volume of incompatible plasma administrated.
From another point of view the risk of high titer units is considered low with group O, post storage, pooled PLT concentrate. However its necessary to establish a (golden standard) method for the determination of antibody titer in order to be able to differentiate accurately the high titer donors.
So, for improving the safety of group O plts we need to define a safe level of antibody titer or reduce the volume of incompatible plasma administrated.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Evaluation of ABO Isoagglutinins Level in Blood Group O Donors|
|Estimated Study Start Date :||October 2020|
|Estimated Primary Completion Date :||September 2021|
|Estimated Study Completion Date :||October 2021|
- Other: withdraw blood samples
withdraw blood sample from gorup O donors
- Decrease the risk of red cell destruction resulting from transfusion of RBCs/ platelet concentrate group O transfusion in urgent cases. [ Time Frame: 2 years ]Using blood group typ "O" For other blood group types without causing any reaction resulting from blood transfusion .
- screening for the best group O donors to use for other groups urgent cases as a reserve for transfusion. [ Time Frame: 2 years ]Using blood group typ "O" For other blood group types without causing any reaction resulting from blood transfusion .