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Allergy to Almond in Children

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT04407104
Recruitment Status : Not yet recruiting
First Posted : May 29, 2020
Last Update Posted : July 21, 2020
Information provided by (Responsible Party):
Central Hospital, Nancy, France

Brief Summary:
Allergy to tree nuts are frequent in children but allergy to almond is one of the less described tree nuts allergy. The main objective of our study is to determine diagnostic values of skin prick-tests and specific IgE to almond in a population of children sensitized to almond and challenged in our unit from november 2013 to march 2020.

Condition or disease Intervention/treatment
Food Allergy in Children Diagnostic Test: skin prick-test

Detailed Description:

Secondary objectives are

  • description of allergic reactions to almond (symptoms, severity)
  • modelisation of eliciting dose to almond in our population
  • evaluation of the association between atopic comorbidities and allergy to almond in children sensitized to almond
  • evaluation of the association between allergy to almond and the importance of skin and sIgE sensitization

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Allergy to Almond in Children: Diagnostic Values and Severity
Estimated Study Start Date : July 20, 2020
Estimated Primary Completion Date : August 31, 2020
Estimated Study Completion Date : September 7, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy

Intervention Details:
  • Diagnostic Test: skin prick-test
    retrospective study on data already collected
    Other Names:
    • specific IgE
    • oral food challenge

Primary Outcome Measures :
  1. diagnostic values of skin prick-test and sIgE to almond [ Time Frame: BASELINE ]

Secondary Outcome Measures :
  1. allergic reactions during oral food challenge [ Time Frame: BASELINE ]
    symptoms and severity

  2. eliciting doses to almond [ Time Frame: BASELINE ]
    ED05, ED10 and ED50

  3. atopic comorbidities [ Time Frame: BASELINE ]
    respiratory allergies, other food allergies, asthma

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
children sensitized to almond and challenged in our unit

Inclusion Criteria:

  • oral food challenge to almond performed in the pediatric allergy department of the University Hospital of Nancy from november 2013 and march 2020

Exclusion Criteria:

  • doubtful or incomplete oral food challenge to almond
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Responsible Party: Central Hospital, Nancy, France Identifier: NCT04407104    
Other Study ID Numbers: 2020PI100
First Posted: May 29, 2020    Key Record Dates
Last Update Posted: July 21, 2020
Last Verified: May 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Central Hospital, Nancy, France:
tree nuts
Additional relevant MeSH terms:
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Food Hypersensitivity
Immune System Diseases
Hypersensitivity, Immediate