Brain TV (Tissue Velocimetry) for Emergency Assessment of Acquired Brain Injury
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Brain motion is highly sensitive to heart and brain biomechanics, but the impact of brain injury on brain tissue motion has yet to be explored. Preliminary brain tissue motion measurements from a small number of patients suggest that brain biomechanics may be disturbed in the presence of injury. This study combines Transcranial Tissue Doppler ultrasound with brain MRI to establish whether analysis of brain tissue motion provides clinically useful information for emergency diagnosis and monitoring of acute brain injury.
The study will generate a library of Brain TV measurements for exploratory (descriptive) analysis and imaging of brain tissue pulsations in patients with acquired brain injury (ABI) to evaluate the potential for clinical device development.
MRI measurement [ Time Frame: Up to 5 days. ]
This study will perform brain MRI for brain tissue motion for selective patients with acquired brain injury
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Participants with suspected acute acquired brain injury will be identified and recruited by the Emergency Department (ED) research team and/or members of the direct care team within the Hyper Acute Stroke Unit (HASU).
Participant (or consultee) is willing and able to give informed consent (or assent) for participation in the study.
Adult, aged 18 years or over.
Suspected Acquired Brain Injury (any severity).
Unable (in the investigators' opinion), or unwilling, to comply with the study requirements.
Patients with pre-existing chronic brain conditions that may make affect informed consent, such as severe learning difficulties, dementia, or Alzheimer's disease, will be excluded.