Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels (COVID-APE)
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|ClinicalTrials.gov Identifier: NCT04373486|
Recruitment Status : Completed
First Posted : May 4, 2020
Last Update Posted : January 11, 2021
Reports of acute pulmonary embolism (APE) associated with COVID-19 have emerged in the literature. For example, Chen et al. described 25 pulmonary CT angiograms examinations from 1008 COVID-19 patients; 10 were positive for pulmonary embolism mostly as segmental or sub-segmental APE. Case reports of APE in Covid-19 patients have been published. Cui et al. found an incidence of deep venous thrombosis in intensive care unit (ICU) patients with severe Covid-19 pneumonia near to 25% (20/81), however without any correlation with potential APE.
Despite these initial reports, it is not clear whether APE is more frequent in Covid-19 patients or if the association is just random. In favor of the former, D-dimer levels have been reported as elevated in patients with Covid-19 by two studies, and it has been suggested an independent association between the severity of the disease and the level of D-dimer. Finally, Tang et al. showed that anticoagulant therapy is associated with a decreased mortality at Day-28 in severe Covid-19 patients, in favor of a possible associated coagulopathy. The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography.
The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography.
|Condition or disease|
|Covid-19 With Positive RT-PCR|
|Study Type :||Observational|
|Actual Enrollment :||160 participants|
|Official Title:||Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels|
|Actual Study Start Date :||March 3, 2020|
|Actual Primary Completion Date :||April 30, 2020|
|Actual Study Completion Date :||May 1, 2020|
- Rate of positivity for Acute Pulmonary Embolism [ Time Frame: March 1, 2020 - March 31, 2020 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04373486
|Service de Radiologie B - NHC|
|Strasbourg, France, 67091|