COVID-19 Epidemic Response Study (COVeR)
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|ClinicalTrials.gov Identifier: NCT04357496|
Recruitment Status : Not yet recruiting
First Posted : April 22, 2020
Last Update Posted : November 24, 2020
|Condition or disease|
|Fever Pneumonia Cough|
By 31st December 2019, 27 subjects with pneumonia of unknown aetiology were registered in Wuhan City, China. 7th of January the disease causative agent was identified and turned to be severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The WHO named the disease - coronavirus disease (COVID-19). On March 11, 2020, the World Health Organization (WHO) announced that COVID-19 should be characterized as a pandemic. At great economic cost, many countries have adopted unprecedented measures to curb the spread of the virus, such as large-scale use of isolation and quarantine, closing borders, imposing limits on public gatherings, and implementing nationwide lockdowns.
The most common symptoms of COVID-19 are fever, tiredness, and dry cough. Some patients may exhibit nasal congestion, runny nose, sore throat or diarrhea. These symptoms are usually mild and begin gradually. About 40% of the symptomatic patients recover from the disease without needing special treatment. Around 1 out of every 6 people infected with SARS-CoV-2 becomes seriously ill and develops difficulty breathing. Older people, and those with underlying medical problems like high chronic cardiovascular and respiratory disease or diabetes, are more likely to develop serious illness.
Monitoring patients with resolution of COVID-19 pneumonia is important in terms of when they should be released from isolation and discharged and to what extent this result is correlating with the clinical severity. If patients are still shedding viable coronavirus, they are likely to infect others. Therefore, quarantine for up to one month may be advisable. The optimal method for test of cure most likely will be two consecutive negative real-time RT-PCR tests. Furthermore, people who have cleared SARS-CoV-2 could have developed specific antibodies against the infectious agent in their blood plasma as a result of humoral immune response. This plasma is rich with specific antibodies and is called convalescent plasma (CP) or convalescent serum (CS). CP could treat and eradicate SARS-CoV-2 in infected individuals and could be used as therapy. This therapy concept was centuries old and was previously attempted during several outbreaks. Currently, there are few reports from China and South Korea showing that patients who received CP transfusion together with antiviral drugs and corticosteroids have recovered from the disease.
It is the aim of the COVeR study to enroll 400 patients with COVID-19 from nursing homes of the german state Mecklenburg-Vorpommern. Each patient will enter a follow-up phase of 6 months during which buccal swaps will be collected for judging the viral load, and blood samples for investigation of their immune response and identifying predictive biomarkers.
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||COVID-19 Epidemic Response Study: A National Observational Longitudinal Non-Interventional Protocol|
|Estimated Study Start Date :||December 20, 2020|
|Estimated Primary Completion Date :||October 30, 2021|
|Estimated Study Completion Date :||November 30, 2021|
Participants with SARS-COV-2
Participants tested positive for SARS-COV-2 aged 60 years or older
- Identification of prognostic parameters for SARS-CoV-2 infected participants. [ Time Frame: 7 months ]Blood samples drawn from the infected participants will be analysed for prognostic parameters.
- Investigation of the kinetics of immune activation and antibody production against SARS-CoV-2 and correlation with clinical course [ Time Frame: 7 months ]Systems from Abbott and Euroimmun will be used for IgG and IgM in SARS-CoV-2.
- Identification of predictive biomarker/s for clinical course in mildly and severely affected Covid-19 patients using genomic, proteomic, and transcriptomic approach. [ Time Frame: 7 months ]Genomic, proteomic, and transcriptomic analyses will be performed on the blood samples drawn from Covid-19 infected participants over the course of 6 months.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04357496
|Contact: Volha Skrahina, PhD||+49 (0)38180113594||Volha.Skrahina@centogene.com|
|Principal Investigator:||Arndt Rolfs, Prof.||Centogene AG Rostock|