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The Efficacy of Ivermectin and Nitazoxanide in COVID-19 Treatment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04351347
Recruitment Status : Not yet recruiting
First Posted : April 17, 2020
Last Update Posted : April 17, 2020
Sponsor:
Information provided by (Responsible Party):
Sherief Abd-Elsalam, Tanta University

Study Description
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Brief Summary:
Efficacy of Ivermectin and Nitazoxanide in COVID-19 treatment

Condition or disease Intervention/treatment Phase
COVID Drug: Chloroquine Drug: Nitazoxanide Drug: Ivermectin Phase 2 Phase 3

Detailed Description:
Clinical Study Evaluating the Efficacy of Ivermectin and Nitazoxanide in COVID-19 treatment
Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Clinical Study Evaluating the Efficacy of Ivermectin and Nitazoxanide in COVID-19 Treatment
Estimated Study Start Date : April 17, 2020
Estimated Primary Completion Date : December 1, 2030
Estimated Study Completion Date : December 1, 2030

Resource links provided by the National Library of Medicine


Arms and Interventions
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Arm Intervention/treatment
Experimental: Chloroquine
Chloroquine
 Drug: Chloroquine
chloroquine
Other Name: alexoquine, chloroquine
Experimental: Nitazoxanide
Nitazoxanide with chloroquine
 Drug: Chloroquine
chloroquine
Other Name: alexoquine, chloroquine

Drug: Nitazoxanide
Nitazoxanide with chloroquine
Other Name: Alenia
Experimental: Ivermectin
Ivermectin with chloroquine
 Drug: Chloroquine
chloroquine
Other Name: alexoquine, chloroquine

Drug: Ivermectin
Ivermectin with chloroquine


Outcome Measures
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Primary Outcome Measures :
  1. Number of patients with virological cure [ Time Frame: 6 months ]
    Number of patients with virological cure


Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with covid 19

Exclusion Criteria:

  • Allergy or side effects to treatment
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04351347


Contacts
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Contact: Sherief Abd-Elsalam, ass. prof. 00201147773440 sheriefabdelsalam@yahoo.com

Locations
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Egypt
Tanta University
Tanta, Egypt, 35111
Sponsors and Collaborators
Tanta University
Investigators
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Principal Investigator: sherief Abd-Elsalam, Ass. Prof. Tanta University - Faculty of Medicine
More Information
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Responsible Party: Sherief Abd-Elsalam, Ass. Prof. Tropical Medicine, Tanta University
ClinicalTrials.gov Identifier: NCT04351347    
Other Study ID Numbers: ivermecin covid
First Posted: April 17, 2020    Key Record Dates
Last Update Posted: April 17, 2020
Last Verified: April 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Chloroquine
Chloroquine diphosphate
Ivermectin
Nitazoxanide
Amebicides
Antiprotozoal Agents
Antiparasitic Agents
Anti-Infective Agents
Antimalarials
Antirheumatic Agents
 Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Filaricides
Antinematodal Agents
Anthelmintics