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Trial record 1 of 39 for:    asymptomatic transmission | COVID-19
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Transmissibility and Viral Load of SARS-CoV-2 in Oral Secretions

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ClinicalTrials.gov Identifier: NCT04348240
Recruitment Status : Recruiting
First Posted : April 16, 2020
Last Update Posted : July 16, 2020
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Dental and Craniofacial Research (NIDCR) )

Brief Summary:

Background:

COVID-19 is a worldwide pandemic and currently there is no effective therapy or vaccine. SARS-CoV-2, the virus that causes the COVID-19 respiratory infection, appears to be very contagious however all the modes of transmission are unclear. Transmission may occur in up to 25 percent of cases when there are no symptoms (asymptomatic). Before there are any symptoms, droplet spray during speaking may increase transmission from person to person; most of the spray is saliva. Researchers at the NIH would like to test saliva for the virus before symptoms are reported. Additionally, they would like to examine the importance of using masks to prevent transmission. They hope to better understand how COVID-19 is spread among people and how it can be prevented.

Objectives:

To determine if the SARS-CoV-2 virus is present in saliva in asymptomatic individuals who are COVID-19 positive.

To determine if using masks can prevent transmission.

Eligibility:

People ages 18 and older without symptoms of COVID-19 who have been in close contact (e.g. live in the same house) with someone who has tested positive for COVID-19 or NIH workers who have tested positive for COVID-19 and have mild or no symptoms. Retested individuals may be enrolled to understand how the disease has progressed and resolved.

Design and Procedures:

For screening, interested participants will contact a study team member. The interested participant will be asked to provide documentation of COVID-19 positive status, their symptoms, or their contact to a COVID-19 positive person.

Participants will have weekly telephone calls to discuss their symptoms and 2-5 drive-up visits to the NIH within 28 days.

At the drive-up facility, participants will participate in a speaking exercise with and without wearing a mask. The droplets they produce while they speak will be collected. Participants will spit into a cup and have saliva collected from different areas of the mouth. They should not eat 90 minutes before this but drinking water or juice is acceptable. They may have their tongue painted with a sour liquid to increase their saliva. Participants will have a swab rubbed inside their nose. For those who are close contacts and need a COVID-19 test, they will have a swab inserted through the nose to rub the back of their throat.

Participants will complete questionnaires about their symptoms electronically at home.

Subjects may be asked to return to the NIH more frequently by the study team based on testing results.

If at any time the participants start to have moderate or severe respiratory symptoms, their participation will end and they should seek care with their local provider.


Condition or disease
COVID-19

Detailed Description:
COVID-19 is a worldwide pandemic without an effective therapy. A series of reports have implicated that asymptomatic transmission occurs in at least 25% SARS-CoV-2 cases. We hypothesize that droplet emission from oral fluids generated during speaking could be an important and actionable factor driving asymptomatic transmission. We aim to collect oral and nasal secretions to test for viral load and viral infectivity in 1) asymptomatic high-risk subjects with unknown SARS-CoV-2 status, but with a history of close personal contact with a SARSCoV- 2 positive person and 2) asymptomatic or mildly symptomatic subjects who are SARS-CoV-2 positive. COVID-19 positive individuals re-testing as negative can be enrolled to complete the electronic questionnaire(s) assessment and allow for evaluation of history of symptoms.

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Transmissibility and Viral Load of SARS-CoV-2 Through Oral Secretions
Actual Study Start Date : April 16, 2020
Estimated Primary Completion Date : July 1, 2021
Estimated Study Completion Date : July 1, 2021

Group/Cohort
1
asymptomatic high-risk subjects with known history of close personal contact with a COVID-19 positive person not tested (SARS-CoV2 status unknown)



Primary Outcome Measures :
  1. To determine SARS-CoV-2 viral load and infectivity in saliva that may contribute to asymptomatic transmission [ Time Frame: Ongoing ]
    Detection of virus in saliva



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
1) asymptomatic high-risk subjects with known history of close personal contact with a COVID-19 positive person not tested (SARS-CoV2 status unknown)2) asymptomatic or mildly symptomatic (fever without cough, sneezing or shortness of breath) subjects who are COVID-19 positive 3) COVID-19 positive individuals retesting negative can be enrolled to complete the electronic questionnaire(s) assessment and allow evaluation of history of symptoms.
Criteria
  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

  1. Willing and able to sign and date the informed consent form
  2. Willing to comply with all study procedures and available for study visits and calls
  3. Male or female, aged >= 18 years of age
  4. Persons who test COVID-19 positive (verbal confirmation followed by documented test results, sent electronically) and are asymptomatic or have mild symptoms (e.g., fever, mild malaise, sore throat or sneezing) individuals who have re-tested and are negative may be enrolled to understand progression and resolution of disease; persons hospitalized at the NIH Clinical Center meeting Inclusion Criteria 1-3 may be enrolled on this study
  5. Persons considered high risk for COVID-19 due to personal contact within the past 7 days with a COVID-19 positive individual (e.g., co-habitating family member of COVID-19 positive) and has no symptoms or mild symptoms of COVID-19 - verbal confirmation followed by documented test results of positive individual, sent electronically

EXCLUSION CRITERION:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. COVID-19 positive subjects with active moderate or severe symptoms of cough or shortness of breath (upper and lower respiratory symptoms) or currently requiring hospitalization at a hospital other than NIH Clinical Center (recovering COVID-19 positive patients can be enrolled).


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04348240


Contacts
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Contact: Eileen M Pelayo (301) 594-3097 eileen.pelayo@nih.gov

Locations
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United States, Maryland
National Institutes of Health Clinical Center Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-411-1222 ext TTY8664111010    prpl@cc.nih.gov   
Sponsors and Collaborators
National Institute of Dental and Craniofacial Research (NIDCR)
Investigators
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Principal Investigator: Blake M Warner, D.D.S. National Institute of Dental and Craniofacial Research (NIDCR)
Additional Information:
Publications:
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Responsible Party: National Institute of Dental and Craniofacial Research (NIDCR)
ClinicalTrials.gov Identifier: NCT04348240    
Other Study ID Numbers: 200094
20-D-0094
First Posted: April 16, 2020    Key Record Dates
Last Update Posted: July 16, 2020
Last Verified: May 18, 2020
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Dental and Craniofacial Research (NIDCR) ):
Saliva
Coronavirus
SARS-CoV-2
Symptoms
COVID19