Neonatal Seizure Registry - Developmental Functional EValuation (NSR-DEV)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT04337697 |
Recruitment Status :
Recruiting
First Posted : April 8, 2020
Last Update Posted : July 6, 2022
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Condition or disease |
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Neonatal Seizure Hypoxic-Ischemic Encephalopathy Stroke Intracranial Hemorrhages Epilepsy Cerebral Palsy Intellectual Disability |
Neonatal seizures due to brain injury (acute symptomatic seizures) are associated with high risk of neurodevelopmental disability in infancy. Although prognosis in early childhood is a critical question for parents and providers, outcomes beyond infancy are largely unknown. Further, parents of infants with neonatal seizures are at risk for mental health disorders, which can undermine their ability to care for a child with medical complexity and may contribute to impaired child development.
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants enrolled at one of nine sites across the USA. Participants will be evaluated using developmental questionnaires and in-person neurodevelopmental testing. Parent well-being will be assessed at each time point.
Study Type : | Observational [Patient Registry] |
Estimated Enrollment : | 280 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Target Follow-Up Duration: | 4 Years |
Official Title: | Neonatal Seizure Registry - Developmental Functional EValuation |
Actual Study Start Date : | March 15, 2020 |
Estimated Primary Completion Date : | February 29, 2024 |
Estimated Study Completion Date : | February 29, 2024 |
- Full scale IQ (FSIQ) score for each child on the Wechsler Preschool and Primary Scale of Intelligence, 4th Edition (WPPSI-IV) [ Time Frame: At age 5.5 years during in-person study visit ]The WPPSI-IV is an in-person assessment administered by a psychologist or psychometrician that will be used to measure neurocognitive ability. Full Scale IQ (FSIQ) will be generated for each participant from the following subtests: Verbal Comprehension Index (VCI), Visual Spatial Index (VSI), Fluid Reasoning Index (FRI), Working Memory Index (WMI), Processing Speed Index (PSI), Receptive Vocabulary and Picture Naming.
- Change in scores over time for each child on the Vineland Adaptive Behavior Scales, 3rd Edition [ Time Frame: At enrollment study visit and annual visits when the child is age 3, 4, 5.5, 7, and 8 ]The Vineland Adaptive Behavior Scales Parent Form measures adaptive behavior and intellectual and developmental function. Adaptive behavior is predictive of functional performance in school and is linked to both cognitive and executive function. Scores for each participant at each timepoint are generated based on parent reports in the following categories: Communication, Daily Living Skills, Socialization, Motor Skills, Adaptive Behavior Composite (ABC). We will look at the change in score over time for each participant during the study period after the Vineland-3 is administered at each timepoint.
- Scores for each child on Behavior Rating Inventory of Executive Function®, Preschool version (BRIEF-P) [ Time Frame: At enrollment study visit ]BRIEF-P is a standardized measure of early childhood executive function. Scores are generated based on parent report of a child's function in the Global Executive Composite (GBC) scale.
- Scores for each child on Behavior Rating Inventory of Executive Function®, Preschool version (BRIEF-P) [ Time Frame: At age 5.5 years during in-person study visit ]BRIEF-P is a standardized measure of early childhood executive function. Scores are generated based on parent report of a child's function in the Global Executive Composite (GBC) scale.
- Scores for each child on The Social Responsiveness Scale, 2nd edition (SRS-2) - Parent Form [ Time Frame: At enrollment study visit ]SRS-2 (Parent Form) is an online tool to identify social impairment associated with Autism Spectrum Disorders and quantifies Autism Spectrum Disorder severity. Scores are generated based on parent report of child's function in these scales: Social Awareness, Social Cognition, Social Communication, Social Motivation, Restricted Behaviors and Repetitive Behavior. A total score as well as separate scale scores are generated.
- Scores for each child on The Social Responsiveness Scale, 2nd edition (SRS-2) - Parent Form [ Time Frame: At age 5.5 years during in-person study visit ]SRS-2 (Parent Form) is an online tool to identify social impairment associated with Autism Spectrum Disorders and quantifies Autism Spectrum Disorder severity. Scores are generated based on parent report of child's function in these scales: Social Awareness, Social Cognition, Social Communication, Social Motivation, Restricted Behaviors and Repetitive Behavior. A total score as well as separate scale scores are generated.
- Scores for each child on The Social Responsiveness Scale, 2nd edition (SRS-2) - Teacher Form [ Time Frame: At age 5.5 years during in-person study visit ]SRS-2 (Teacher Form) is an online tool to identify social impairment associated with Autism Spectrum Disorders and quantifies Autism Spectrum Disorder severity. Scores are generated based on teacher report of child's function in these scales: Social Awareness, Social Cognition, Social Communication, Social Motivation, Restricted Behaviors and Repetitive Behavior. A total score as well as separate scale scores are generated.
- Scores for each child on Behavior Assessment System for Children, 3rd edition (BASC-3) - Parent Form [ Time Frame: At enrollment study visit ]BASC-3 (Parent Form) is a measure of both adaptive and problem behaviors. Scores are generated based on parent report of a child's behavior in these scales: Externalizing Problems, Internalizing Problems, Adaptive Skills, Hyperactivity, Attention Problems, Atypicality, and Social Skills.
- Scores for each child on Behavior Assessment System for Children, 3rd edition (BASC-3) - Parent Form [ Time Frame: At age 5.5 years during in-person study visit ]BASC-3 (Parent Form) is a measure of both adaptive and problem behaviors. Scores are generated based on parent report of a child's behavior in these scales: Externalizing Problems, Internalizing Problems, Adaptive Skills, Hyperactivity, Attention Problems, Atypicality, and Social Skills.
- Scores for each child on Behavior Assessment System for Children, 3rd edition (BASC-3) - Teacher Form [ Time Frame: At age 5.5 years during in-person study visit ]BASC-3 (Teacher Form) is a measure of both adaptive and problem behaviors. Scores are generated based on teacher report of a child's behavior in these scales: Externalizing Problems, Internalizing Problems, Behavior Symptoms Index, Adaptive Skills, School Problems, Hyperactivity, Attention Problems, Atypicality, and Social Skills.
- Scores for each child on Child Sensory Profile, 2nd edition - Parent Form [ Time Frame: At enrollment study visit ]Child Sensory Profile, 2nd edition (Parent Form) is a standardized instrument to evaluate sensory processing issues, including oversensitivity to sights, sounds, textures, and other sensory input. Scores are generated based on parent report of child's processing in these areas: Seeking/Seeker, Avoiding/Avoider, Sensitivity/Sensor, Registration/Bystander, Auditory Processing, Visual Processing, Touch Processing, Movement Processing, Body Position Processing, and Oral Sensory Processing.
- Scores for each child on Child Sensory Profile, 2nd edition - Parent Form [ Time Frame: At age 5.5 years during in-person study visit ]Child Sensory Profile, 2nd edition (Parent Form) is a standardized instrument to evaluate sensory processing issues, including oversensitivity to sights, sounds, textures, and other sensory input. Scores are generated based on parent report of child's processing in these areas: Seeking/Seeker, Avoiding/Avoider, Sensitivity/Sensor, Registration/Bystander, Auditory Processing, Visual Processing, Touch Processing, Movement Processing, Body Position Processing, and Oral Sensory Processing.
- Scores for each child on Kaufman Test of Educational Achievement, 3rd edition (KTEA-3) [ Time Frame: At age 5.5 years during in-person study visit ]KTEA-3 is a standardized instrument that provides in-depth assessment and evaluation of key academic skills. Scores are generated based on child performance in these areas: Spelling, Letter and Word Recognition and Math Computation.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At enrollment study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At (child) age 3 years during annual study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At (child) age 4 years during annual study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At (child) age 5.5 years during in-person study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At (child) age 7 years during annual study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on Hospital Anxiety Depression Scale (HADS) [ Time Frame: At (child) age 8 years during annual study visit ]Hospital Anxiety Depression Scale (HADS) is a well-validated, 14-item, measure of symptoms of anxiety and depression. Scores will be generated based on parent/guardian response to the HADS questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At enrollment study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At (child) age 3 years during annual study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At (child) age 4 years during annual study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At (child) age 5.5 years during in-person study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At (child) age 7 years during annual study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on WHO Quality of Life-BREF (WHOQOL-BREF) [ Time Frame: At (child) age 8 years during annual study visit ]WHO Quality of Life-BREF (WHOQOL-BREF) assesses four domains of health: physical, psychological, social relationships, and environment. It also includes two general questions on self-perceived QOL and general health. Scores will be generated based on parent/guardian response to the WHOQOL-BREF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At enrollment study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At (child) age 3 years during annual study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At (child) age 4 years during annual study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At (child) age 5.5 years during in-person study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At (child) age 7 years during annual study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact on Family Scale (IOF) [ Time Frame: At (child) age 8 years during annual study visit ]The Impact on Family Scale (IOF) measures parent perception of the ill child's impact on the family. The score represents a construct of personal, family and social impact. Scores will be generated based on parent/guardian response to the IOF questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At enrollment study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At (child) age 3 years during annual study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At (child) age 4 years during annual study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At (child) age 5.5 years during in-person study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At (child) age 7 years during annual study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Impact of Events Scale - Revised [ Time Frame: At (child) age 8 years during annual study visit ]The Impact of Events Scale - Revised is a validated measure of post-traumatic stress reactions. Scores will be generated based on parent/guardian response to the Impact of Events Scale - Revised questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At enrollment study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At (child) age 3 years during annual study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At (child) age 4 years during annual study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At (child) age 5.5 years during in-person study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At (child) age 7 years during annual study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Scores for each parent/guardian on The Post Traumatic Growth Inventory [ Time Frame: At (child) age 8 years during annual study visit ]The Post Traumatic Growth Inventory is a commonly used, validated measure of resilience that has been incorporated into studies of parents of sick neonates and children. Scores will be generated based on parent/guardian response to The Post Traumatic Growth Inventory questionnaire.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At enrollment study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At (child) age 3 years during annual study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At (child) age 4 years during annual study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At (child) age 5.5 years during in-person study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At (child) age 7 years during annual study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.
- Written responses from each parent/guardian on Open Ended Questions [ Time Frame: At (child) age 8 years during annual study visit ]The Open Ended Questions ask parents/guardians to explain different aspects of caring for their child and their child's healthcare journey and for any advice they would give to both the healthcare team and other parents of children with similar conditions.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 2 Years to 8 Years (Child) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Enrolled in NSR-II
- Alive at the start of the NSR-DEV study period
- Parent(s) who are English or Spanish literate (with assistance of interpreter)
Exclusion Criteria:
- Neonates who were found to have exclusion criteria after NSR-II enrollment
- Risk for adverse outcome independent of seizures and underlying brain injury (including but not limited to: inborn errors of metabolism, fetal infection, brain malformation)
- Transient cause for seizures (e.g., mild hypoglycemia, hyponatremia, hypocalcemia with normal neuroimaging)
- Neonatal-onset epilepsy syndromes

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04337697
Contact: Hannah C. Glass, MDCM, MAS | 415-476-3785 | Hannah.glass@ucsf.edu | |
Contact: Yasmeen A. Rezaishad, BS | 415-476-3785 | Yasmeen.rezaishad@ucsf.edu |
United States, California | |
University of California, San Francisco | Recruiting |
San Francisco, California, United States, 94158 | |
Contact: Yasmeen A. Rezaishad, BS 415-476-3785 yasmeen.rezaishad@ucsf.edu | |
Principal Investigator: Hannah C. Glass, MDCM, MAS | |
Sub-Investigator: Charles McCulloch, PhD | |
Sub-Investigator: Elizabeth E. Rogers, MD | |
Sub-Investigator: Linda S. Franck, PhD, RN, FAAN | |
Sub-Investigator: Yi Li, MD | |
Stanford University | Recruiting |
Stanford, California, United States, 94304 | |
Contact: Sweta Patnaik, MS 650-721-1458 sweta@stanford.edu | |
Principal Investigator: Courtney J. Wusthoff, MD | |
United States, District of Columbia | |
Children's National Medical Center | Recruiting |
Washington, District of Columbia, United States, 20010 | |
Contact: Ruoying (Penny) Li 202-476-3807 rli@childrensnational.org | |
Principal Investigator: Taeun Chang, MD | |
United States, Massachusetts | |
Massachusetts General Hospital | Recruiting |
Boston, Massachusetts, United States, 02114 | |
Contact: Erin Berja, BS 617-249-4939 eberja@mgh.harvard.edu | |
Principal Investigator: Catherine Chu, MD | |
Boston Children's Hospital | Recruiting |
Boston, Massachusetts, United States, 02115 | |
Contact: Jessica Landers, MS 617-355-0578 jessica.landers@childrens.harvard.edu | |
Principal Investigator: Janet Soul, MD | |
United States, Michigan | |
University of Michigan | Recruiting |
Ann Arbor, Michigan, United States, 48109 | |
Contact: Stephanie Rau, BS, CCRP 734-232-8474 shatchew@med.umich.edu | |
Principal Investigator: Renee A. Shellhaas, MD, MS | |
United States, North Carolina | |
Duke University | Recruiting |
Durham, North Carolina, United States, 27705 | |
Contact: Caitlin Stone, MA 919-668-1775 caitlin.stone@duke.edu | |
Principal Investigator: Monica E. Lemmon, MD | |
United States, Ohio | |
Cincinnati Children's Hospital Medical Center | Recruiting |
Cincinnati, Ohio, United States, 45229 | |
Contact: Victor LaFay, MBA, CCRP 513-803-1988 victor.lafay@cchmc.org | |
Principal Investigator: Cameron Thomas, MD, MS | |
United States, Pennsylvania | |
Children's Hospital of Philadelphia | Recruiting |
Philadelphia, Pennsylvania, United States, 19104 | |
Contact: Darshana Parikh, BA parikhd@email.chop.edu | |
Principal Investigator: Nicholas Abend, MD, MSCE |
Principal Investigator: | Hannah C. Glass, MDCM, MAS | University of California, San Francisco |
Responsible Party: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT04337697 |
Other Study ID Numbers: |
19-28584 1R01NS111166-01A1 ( U.S. NIH Grant/Contract ) R01NS111166 ( U.S. NIH Grant/Contract ) |
First Posted: | April 8, 2020 Key Record Dates |
Last Update Posted: | July 6, 2022 |
Last Verified: | July 2022 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Yes |
Plan Description: | In accordance with study sponsor |
Time Frame: | In accordance with study sponsor |
Access Criteria: | In accordance with study sponsor |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Family impact Neurodevelopment |
Cerebral Palsy Seizures Brain Diseases Intellectual Disability Brain Ischemia Hypoxia-Ischemia, Brain Intracranial Hemorrhages Hemorrhage Central Nervous System Diseases Nervous System Diseases Pathologic Processes |
Brain Damage, Chronic Neurologic Manifestations Hypoxia Signs and Symptoms, Respiratory Neurobehavioral Manifestations Neurodevelopmental Disorders Mental Disorders Cerebrovascular Disorders Vascular Diseases Cardiovascular Diseases Hypoxia, Brain |