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The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04292106
Recruitment Status : Completed
First Posted : March 2, 2020
Last Update Posted : January 14, 2022
Sponsor:
Information provided by (Responsible Party):
Jeremy Townsend, Lipscomb University

Brief Summary:
Red Spinach is a natural food which is a rich source of nitrates, which are beneficial in hemodynamics, cardiovascular function, and have natural hypotensive and antianginal effects. Red spinach extract has been shown to be beneficial in exercise performance, albeit mostly in aerobic exercise. In a previous study in our lab, we found that dietary nitrate consumption resulted in significantly greater isometric force production in teenage males. However, currently there is little know regarding the effects of dietary nitrate supplementation on isometric strength, resistance exercise and cognitive performance.

Condition or disease Intervention/treatment Phase
Sports Dietary Supplement: Red Spinach Extract (RSE) Dietary Supplement: Placebo Not Applicable

Detailed Description:
This research study is designed to measure the effects of red spinach extract (RSE) on markers of physical and cognitive performance during and following anaerobic exercise.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance.
Actual Study Start Date : September 26, 2019
Actual Primary Completion Date : March 30, 2020
Actual Study Completion Date : March 30, 2020

Arm Intervention/treatment
Placebo Comparator: Placebo Dietary Supplement: Placebo
Oral placebo capsules will be taken consisting of maltodrextrin daily for 7 days

Experimental: Red Spinach Extract (RSE) Dietary Supplement: Red Spinach Extract (RSE)
Oral capsules containing 2g of Red Spinach Extract will be consumed daily for 7 days




Primary Outcome Measures :
  1. Bench Press Repetitions to Fatiuge [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    Number of repetitions completed in each set during the acute exercise bout will be recorded and analyzed

  2. Bench Press Power [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    Power during bench press repetitions will be measured via a linear transducer.

  3. Isometric Mid-thigh pull (IMTP) Peak Force [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    Peak Force will be measured via dual force plates during a full-body isometric strength test.

  4. Isometric Mid-thigh pull (IMTP) Rate of Force Development [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    Rate of Force development will be measured via dual force plates during a full-body isometric strength test.


Secondary Outcome Measures :
  1. Estimated Muscle Blood Flow via Near-infrared Spectroscopy (NIRS) [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    Measures of muscle oxygenation of the anterior deltoid will be estimated using a NIRS Device.

  2. Cognitive Performance via Stroop Test [ Time Frame: Through study completion, during both treatments (~4 weeks) ]
    The Stroop Color and Word Test (SCWT) is a neuropsychological test used to assess cognitive performance. This will be administered before and after the fatiguing bench press protocol



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Ages Eligible for Study:   18 Years to 34 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18-34 years old Participants must have at least 1 year of resistance training experience.
  • Free of any physical limitations, medications, and supplements that may affect performance, as determined by a health and activity questionnaire.
  • Are free of musculoskeletal injuries
  • Are not taking medications that may interfere with study measurements

Exclusion Criteria:

  • Participants that cannot take either the RSE or placebo supplement will be excluded, as this will be a double-blind study.
  • Furthermore, participants that cannot participate in pre- and post-research testing, and/or those that cannot commit to regular training sessions will be excluded.
  • Inability to perform physical exercise (determined by health and activity questionnaire)
  • Taking any other nutritional supplement or performance enhancing drug.
  • Any chronic illness that causes continuous medical care

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04292106


Locations
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United States, Tennessee
Jeremy Townsend
Nashville, Tennessee, United States, 37215
Sponsors and Collaborators
Lipscomb University
Investigators
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Principal Investigator: Jeremy Townsend, PhD Lipscomb University
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Responsible Party: Jeremy Townsend, Assistant Professor, Lipscomb University
ClinicalTrials.gov Identifier: NCT04292106    
Other Study ID Numbers: 092619
First Posted: March 2, 2020    Key Record Dates
Last Update Posted: January 14, 2022
Last Verified: January 2022

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No