Endoscopic Findings of Gastritis in Children

• ClinicalTrials.gov Identifier: NCT04289519
• Recruitment Status: Unknown
• First Posted: February 28, 2020
• Last Update Posted: February 28, 2020
• Sponsor: Assiut University
• Information provided by (Responsible Party): HM Reyad, Assiut University

Study Description

Brief Summary:

Gastritis defines any (histologically confirmed) inflammation of the gastric mucosa

Condition or disease
Gastritis

Detailed Description:

Gastritis is a very common disease in children. The main presentation of children with gastritis is recurrent abdominal pain and dyspepsia or vomiting. Young children may have hematemesis or melena as presentation. Drug induced or food related gastritis presents usually with acute symptoms but Helicobacter pylori gastritis have mainly recurrent abdominal pain and dyspeptic symptoms. Other presentations include diarrhea, constipation, flatulence, bloating, fatigue, low energy level, weight loss, muscle loss, bad breath etc.

The main causes of gastritis are infections, inflammation and other disorders affect the gastric mucosa in pediatric patients. Helicobacter pylori infection is the most common cause of gastritis in children which is also responsible for the majority of duodenal ulcers.

Acute erosive gastritis is most commonly the result of metabolic stress or drug or corrosive injury.

Other major causes of gastritis include celiac disease, allergic disorders, and Crohn's disease .Medication as NSAIDs, uremia, ischemia, shock, radiation, sepsis, trauma, severe burns and surgery.

Endoscopic pictures in acute gastritis may be in the form of:

• Multiple round-shaped severe erosions with a diameter of several millimeters.
• Mucosal edema, hyperemia.
• Peptic ulcer While in chronic gastritis is variable. Affects the antrum in the beginning and advances to the proximal in time .

Study Design

• Study Type: Observational
• Estimated Enrollment: 500 participants
• Observational Model: Case-Control
• Time Perspective: Retrospective
• Official Title: Retrospective Study on Endoscopic Findings of Gastritis in Children Attending GIT Endoscopic Unit of Assiut University Children Hospital (AUCH) (15 Years)
• Estimated Study Start Date: September 30, 2020
• Estimated Primary Completion Date: October 30, 2020
• Estimated Study Completion Date: April 30, 2021

Groups and Cohorts

Outcome Measures

Primary Outcome Measures :

1. causes of gastritis in children as shown by upper endoscopy [ Time Frame: average 1 year ]
   • infections
   • inflammation
   • Helicobacter pylori
   • Acute erosive gastritis

Eligibility Criteria

• Ages Eligible for Study: up to 18 Years (Child, Adult)
• Sexes Eligible for Study: All
• Sampling Method: Non-Probability Sample

Study Population

All children diagnosed as gastritis by upper endoscopy and bio gastric biopsy

Criteria

Inclusion Criteria:

• All children diagnosed as gastritis by upper endoscopy and bio gastric biopsy

Exclusion Criteria:

• • All children underwent upper endoscopy during the study period not diagnosed as gastritis

Contacts and Locations

Contacts

Contact: Naglaa Hassan, Professor; 01111872237; naglaa.ibrahim@med.au.edu.eg

Contact: Amira Mohamed, Lecturer; 01223958949; amira.shalabi@med.au.edu.eg

Sponsors and Collaborators

Assiut University

More Information

Publications:

Pasechnikov VD, Chukov SZ, Kotelevets SM, Mostovov AN, Mernova VP, Polyakova MB. Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. Scand J Gastroenterol. 2005 Mar;40(3):297-301. doi: 10.1080/00365520410010607.

Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006 Jul;19(3):449-90. doi: 10.1128/CMR.00054-05.

Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Macarthur C, Snyder J, Sherman PM; North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr. 2000 Nov;31(5):490-7. doi: 10.1097/00005176-200011000-00007. No abstract available.

Tam YH, Chan KW, To KF, Cheung ST, Mou JW, Pang KK, Wong YS, Sihoe JD, Lee KH. Impact of pediatric Rome III criteria of functional dyspepsia on the diagnostic yield of upper endoscopy and predictors for a positive endoscopic finding. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):387-91. doi: 10.1097/MPG.0b013e31820e2026.

Glickman JN, Antonioli DA. Gastritis. Gastrointest Endosc Clin N Am. 2001 Oct;11(4):717-40, vii.

Kayacetin S, Guresci S. What is gastritis? What is gastropathy? How is it classified? Turk J Gastroenterol. 2014 Jun;25(3):233-47. doi: 10.5152/tjg.2014.7906.

• Responsible Party: HM Reyad, principle investigator, Assiut University
• ClinicalTrials.gov Identifier: NCT04289519
• Other Study ID Numbers: EFOGIC
• First Posted: February 28, 2020
• Last Update Posted: February 28, 2020
• Last Verified: February 2020

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:

Gastritis; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Stomach Diseases