Working… Menu

Eye Movement and Cognitive Dysfunction (EMCD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT04236375
Recruitment Status : Not yet recruiting
First Posted : January 22, 2020
Last Update Posted : January 22, 2020
Information provided by (Responsible Party):
Haotian Lin, Sun Yat-sen University

Brief Summary:
There is association between eye movement disorder and cognitive dysfunction. Therefore, utilizing eye movement and screening for cognitive dysfunction is feasible. In the present study, we will develop an artificial intelligence platform to screening for cognitive dysfunction by inspecting the function of eye movement. Futher more, based on the screening results, the platform will offer referral suggestions.

Condition or disease
Eye Movement Disorder Cognitive Dysfunction

Layout table for study information
Study Type : Observational
Estimated Enrollment : 700 participants
Observational Model: Case-Crossover
Time Perspective: Cross-Sectional
Official Title: The Development of an Artificial Intelligence Platform for Screening and Referral of Cognitive Dysfunction
Estimated Study Start Date : February 1, 2020
Estimated Primary Completion Date : August 1, 2020
Estimated Study Completion Date : December 1, 2020

Resource links provided by the National Library of Medicine

Subjects over 45 years old without cognitive dysfunction
Mild cognitive decline
Subjects who are diagnosed as mild cognitive decline(MCI) according to neurologists.
Alzheimer's disease
Subjects who are diagnosed as Alzheimer's disease(AD) according to neurologists.
Vascular dementia
Subjects who are diagnosed as vascular dementia(VD) according to neurologists.
Lewy body dementia
Subjects who are diagnosed as Lewy body demenita (DLB) according to neurologists.
Frontotemporal dementia
Subjects who are diagnosed as Frontotemporal demenita (FD) according to neurologists.
Other dementia
Subjects who are diagnosed as dementia but are not as AD, VD, DLB OR FD.

Primary Outcome Measures :
  1. Area under the curve [ Time Frame: up to 1 month ]
    AUC values for predicting whether subject has cognitive impairment or not

Secondary Outcome Measures :
  1. Accuracy, true positive rate, and true negetive rate [ Time Frame: up to 1 month ]
    The performance of this artificial platform

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   45 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects who are over 45 years old with or without cognitive dysfunction.

Inclusion Criteria:

  • ①Subjects who are diagnosed as mild cognitive decline, Alzheimer's disease, Vascular dementia, Lewy body dementia, Frontotemporal dementia, other dementia and normal by neurologist.
  • ②Subjects who can cooperate with the inspection.
  • ③Subjects who agree to participate in the study and sign the consent form

Exclusion Criteria:

  • ①Subjects who cannot do the inspection.
  • ②Subjects who suffer from diseases that compromise the inspection.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT04236375

Layout table for location contacts
Contact: Haotian Lin, M.D.,Ph.D 86-13802793086

Sponsors and Collaborators
Sun Yat-sen University
Layout table for investigator information
Study Chair: Haotian Lin, M.D.,Ph.D Zhongshan Ophthalmic Center, Sun Yat-sen University
Study Director: Xun Wang, M.D.,Ph.D Zhongshan Ophthalmic Center, Sun Yat-sen University
Principal Investigator: Shuyi Zhang, M.D. Zhongshan Ophthalmic Center, Sun Yat-sen University
Layout table for additonal information
Responsible Party: Haotian Lin, Professor, Sun Yat-sen University Identifier: NCT04236375    
Other Study ID Numbers: Eye movement-cognitive decline
First Posted: January 22, 2020    Key Record Dates
Last Update Posted: January 22, 2020
Last Verified: January 2020

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
Layout table for MeSH terms
Movement Disorders
Ocular Motility Disorders
Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Central Nervous System Diseases
Nervous System Diseases
Cranial Nerve Diseases
Eye Diseases