Effects of Hyperthermic Baths on Motor Symptoms of Parkinson's Disase
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|ClinicalTrials.gov Identifier: NCT04165278|
Recruitment Status : Completed
First Posted : November 15, 2019
Last Update Posted : November 15, 2019
The seasonal variation of motor and non-motor symptoms of Parkinson's disease (PD) has been receiving attention all the time. Two potential elements (temperature and sunlight) may explains how the seasonal variation could affect PD.
In clinical practice, part of PD patients from Jiangsu province complained that the motor symptoms of PD in winter (low temperature, less sunlight) were more severe than in summer. Seasonal variation in temperature may affect seasonal changes in the severity of PD. An investigation of hallucinations involving 51 PD patients reported no evidence of seasonal variations in clinical symptoms. However, the non-motor symptoms (NMS) in PD fluctuated throughout the year, with winter months being more severe than summer month s in a recent Cross - sectional retrospective study on 372 consecutive PD patients. Moreover, a study of 546 PD patients indicated no seasonal fluctuation in motor symptom severity, when measured with the Unified Parkinson's disease Rating Scale (UPDRS). We considered that seasonal fluctuations of motor symptoms of PD may be related to changes in temperature and sunlight, but light therapy has made some progress in the treatment of PD. Therefore, we began to ask these PD patients who were affected by temperature changes whether their motor symptoms were affected by hyperthermic baths.
In clinical practice, PD patients who complained that motor symptoms were more severe in winter felt the improvement of motor symptoms after HTB. Based on the current situation, we will conduct HTB study to further evaluate whether temperature is an important factor affecting the motor symptoms of PD patients, and the feasibility and effectiveness of simple HTB to improve the motor symptoms of PD.
|Condition or disease||Intervention/treatment||Phase|
|Parkinson Disease||Other: hyperthermic baths||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of Hyperthermic Baths on Motor Symptoms of Parkinson's Disase|
|Actual Study Start Date :||November 1, 2018|
|Actual Primary Completion Date :||September 27, 2019|
|Actual Study Completion Date :||October 18, 2019|
Experimental: After hyperthermic baths
On the first, third and fifth day of the first week, each subject took the HTB at the same time. They would receive subjective measures before and after HTB.
Other: hyperthermic baths
Taking hyperthermic baths
- the Movement Disorder Society - United Parkinson's Disease Rating Scale (MDS-UPDRS) part III motor examination total scores Rating Scale [ Time Frame: 3 week ]score declined
- the modified Webster Symptoms Score [ Time Frame: 3 week ]score declined
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04165278
|Nanjing, Jiangsu, China, 210000|
|Study Director:||Yingdong Zhang, PhD||Nanjing Medical University|