Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04164771
Recruitment Status : Not yet recruiting
First Posted : November 15, 2019
Last Update Posted : December 18, 2019
Sponsor:
Collaborator:
Muhammad Safdar Ali
Information provided by (Responsible Party):
NASEER AHMED, Aga Khan University

Study Description
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:
Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics. It also has positive effect on cardiovascular health and carries a number of beneficial effects on the whole body functions and systems. Aerobic training can also decrease the risk of heart disease in the individual's life.The Moringa leaves are the rich source of minerals, vitamins and other essential phytochemicals. Moringa leave have found to be very effective in many disease particularly diabetic, blood pressure, dyslipidemia and cancer.

Condition or disease Intervention/treatment Phase
Dyslipidemias Other: Aerobic training and Moringa Oleifera Not Applicable

Detailed Description:
Aerobic training is an important component for health in daily life as well as sports performance. Aerobic training improves overall health, reduces body fat, maintain body weight, resting blood pressure (systolic and diastolic), maximal oxygen consumption adequate blood supply and provision of oxygen to the body muscles .The studies reveal that aerobic training is valuable for improving cardiovascular health, fitness and quality of life. On account of lack of aerobic engagement around 17 % of the population suffer from heart related ailment, 12 % from diabetes and 10 % from breast cancer. American College of Sports Medicine suggested that 30 minutes of aerobic workout has progressive effects on physical fitness and especially on chronic diseases. Physically fit individuals have got the potential to affectively cope with stress and anxiety and coronary arteries diseases. Aerobic training can raise maximal oxygen uptake, which means body adapts to use oxygen more efficiently during physical activities. Resultantly, the heart becomes efficient and stronger; meaning that the heart doesn't have to work hard to pump blood in resting position. Aerobic training decreases resting heart rate and may increase blood volume and blood plasma. Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status . Moringa leaves are rich source of vitamins and protein. The Moringa oleifera leaves, flowers, seeds and pods are commonly used as vegetables diet in different regions of south Asia. Moringa plant products are sources of vitamin A, b, C and proteins, including the essential amino acids. Moringa Oleifera leaves can be merged in the feed of birds, animals and human which provide wonderful source of protein other than expensive ingredients. The Moringa oil is used in cooking products as well as for lubrication. There are scientific indications that Moringa Oleifera holds therapeutic potential for hyperlipidemia, diabetes and cardiovascular diseases. The use of herbal supplements has increased rapidly during the first decade of the twentieth century. The nutrients of Moringa are considered to be useful for disorders including skin disease, malnutrition and sexual problem.Different experimental studies has described that Moringa oleifera leaves have therapeutic potential for chronic hyperglycemia and dyslipidemia . Moringa Oleifera is used as a hypolipidemic medication to improve the lipid profile of rats fed on atherogenic diet. Moringa Oleifera intake is more effective in prevention than in treatment of hyperlipidemia.It is documented that overuse of Moringa supplements can cause high increase of iron. Hence, a daily 70 g quantity of Moringa is recommended to be batter and preventive for accumulation of nutrients.This research study is due to be conducted to determine the effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance
Study Design
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Estimated Study Start Date : February 2020
Estimated Primary Completion Date : April 2020
Estimated Study Completion Date : July 2020
Arms and Interventions
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Arm Intervention/treatment
Experimental: Moringa Group
Participants will receive 5-7g of moringa diet daily for 6 weeks.
 Other: Aerobic training and Moringa Oleifera
Aerobic exercises/training refers to any type of rhythmic, continuous physical activities that use large group of muscles like walking, running, cycling, and swimming consuming additional amount of energy while Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status
Experimental: Aerobic training Group
Participants will receive 5-7g of moringa diet daily and will do 30 minutes of aerobic training daily for 6 weeks.
 Other: Aerobic training and Moringa Oleifera
Aerobic exercises/training refers to any type of rhythmic, continuous physical activities that use large group of muscles like walking, running, cycling, and swimming consuming additional amount of energy while Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status
Experimental: Moringa and Aerobic training
Participants will do 30 minutes of aerobic training daily for 6 weeks
 Other: Aerobic training and Moringa Oleifera
Aerobic exercises/training refers to any type of rhythmic, continuous physical activities that use large group of muscles like walking, running, cycling, and swimming consuming additional amount of energy while Moringa Oleifera a plant from the family Moringacea, its products are used as a health supplement introduced in Africa and south Asian countries to cure many diseases and improve health status
No Intervention: Control Group (T4)
Participants will not recieve any treatment


Outcome Measures
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Positive effect of aerobic training and Moringa Oleifera on dyslipidemia and cardiac endurance [ Time Frame: 6 weeks ]
    Change in level of HDL, LDL and triglyceride, impact on cardiac endurance


Eligibility Criteria
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Gender Based Eligibility:   Yes
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy and no medical conditions.
  • LDL level should be 160-189 mg/dl
  • HDL level should be < 40 mg/dl
  • Tri glyceride level should be 200-499 mg/dl
  • Total cholesterol level should be > 200 mg/dl).
  • Beep Test score should be less than 10.5 or less than 40% vo2 max

Exclusion Criteria:

  • Any disease condition as anemia, physical injuries, chronic disease
  • Not capable of doing aerobic training
Contacts and Locations
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04164771


Contacts
Layout table for location contacts
Contact: Naseer Ahmed, Ph.D 03333382013 ext 4465 dr.naseer99@gmail.com
Contact: Javeria Farooq, M.Phil 03343585849 javeria.farooq@aku.edu

Sponsors and Collaborators
Aga Khan University
Muhammad Safdar Ali
Investigators
Layout table for investigator information
Principal Investigator: Naseer Ahmed, Ph.D Agha Khan Hospital
More Information
Go to 
Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information
Layout table for additonal information
Responsible Party: NASEER AHMED, Assistant Professor, Aga Khan University
ClinicalTrials.gov Identifier: NCT04164771    
Other Study ID Numbers: NA 125
First Posted: November 15, 2019    Key Record Dates
Last Update Posted: December 18, 2019
Last Verified: December 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by NASEER AHMED, Aga Khan University:
Aerobic training
Moringa
Cardioprotection
Additional relevant MeSH terms:
Layout table for MeSH terms
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases