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Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction

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ClinicalTrials.gov Identifier: NCT04127591
Recruitment Status : Not yet recruiting
First Posted : October 15, 2019
Last Update Posted : October 15, 2019
Sponsor:
Information provided by (Responsible Party):
Bin He, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Brief Summary:
The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.

Condition or disease Intervention/treatment
Myocardial Infarction Other: exosome

Detailed Description:
Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.

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Study Type : Observational
Estimated Enrollment : 10 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction
Estimated Study Start Date : October 20, 2019
Estimated Primary Completion Date : December 30, 2021
Estimated Study Completion Date : December 30, 2021

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Group/Cohort Intervention/treatment
myocardial infarction group
Patients admitted with the diagnosis of myocardial infarction.
Other: exosome
Collect exosomes in peripheral blood of patients and extract miRNAs from them.

Blank control group
Patients admitted without the diagnosis of myocardial infarction.
Other: exosome
Collect exosomes in peripheral blood of patients and extract miRNAs from them.




Primary Outcome Measures :
  1. Determination of differential expression of miRNA by second-generation sequencing technology [ Time Frame: Day 7 ]

Secondary Outcome Measures :
  1. Diagnostic value of the differential microRNAs evaluate by qPCR in patients of myocardial infarction [ Time Frame: Day 7 ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 100 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients of myocardial infarction
Criteria

Inclusion Criteria:

  • Age > 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent

Exclusion Criteria:

  • Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04127591


Contacts
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Contact: Bin He 021-25077828 hebinicu@139.com

Locations
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China, Shanghai
Ethics Committee of Xinhua Hospital
Shanghai, Shanghai, China, 200092
Sponsors and Collaborators
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

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Responsible Party: Bin He, M.D./Ph.D., Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
ClinicalTrials.gov Identifier: NCT04127591     History of Changes
Other Study ID Numbers: XH-19-010
First Posted: October 15, 2019    Key Record Dates
Last Update Posted: October 15, 2019
Last Verified: October 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Myocardial Infarction
Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases