Predicting Outcome Following Standardized Exercise Therapy in Knee Osteoarthritis Patients
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|ClinicalTrials.gov Identifier: NCT04123756|
Recruitment Status : Terminated (Recruitment issues due to the corona virus and lack of funding to continue)
First Posted : October 11, 2019
Last Update Posted : January 14, 2021
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients. Mechanistic pain profiling aims to identify the underlying mechanisms in the peripheral and central nervous systems, which are associated to the clinical pain.
In addition, the mechanisms underlying the pain relieving effect of standardized exercise therapy are largely unknown, but it is hypothesized that they are linked to the patient's ability to activate the descending pain inhibitory pathways (conditioned pain modulation, CPM) in the central nervous system. Mechanistic pain profiling including CPM have been used prognostic to identify responders to treatment, but these measures as a prognostic tool for standardized exercise therapy has not been investigated.
The primary aim of this study is to investigate if mechanistic pain profiling alone or in combination with clinical pain measures before standardized exercise therapy can predict the patients' pain reduction following the exercise therapy program
|Condition or disease||Intervention/treatment|
|Knee Osteoarthritis||Behavioral: standardized exercise therapy for knee OA patients|
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Smerteprofiler Som Redskab Til at prædiktere Effekten af 6-8 Ugers GLA:D®-forløb Hos Patienter Med Smertefuld Slidgigt i knæene|
|Actual Study Start Date :||October 1, 2019|
|Actual Primary Completion Date :||December 31, 2020|
|Actual Study Completion Date :||December 31, 2020|
- Behavioral: standardized exercise therapy for knee OA patients
Standardized exercise therapy for 6-8 weeks (two times per week).
- pain reduction [ Time Frame: 1-2 weeks after last exercise session ]Pain measured on a numerical rating scale from 0 (no pain) to 10 (worst pain imaginable)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04123756
|Aarhus, Denmark, 8000|