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Cortical Excitability and Role of rTMS in Cannabis Use Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT04106336
Recruitment Status : Not yet recruiting
First Posted : September 27, 2019
Last Update Posted : September 27, 2019
Information provided by (Responsible Party):
Asmaa Omar Radwan Helal, Assiut University

Brief Summary:
Repetitive transcranial magnetic stimulation (rTMS) and cortical excitability have a role in cannabis use disorder

Condition or disease Intervention/treatment Phase
Cannabis Use Disorder, Moderate Device: rTMS Early Phase 1

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cortical Excitability and Role of rTMS in Cannabis Use Disorder
Estimated Study Start Date : October 1, 2019
Estimated Primary Completion Date : October 1, 2020
Estimated Study Completion Date : December 30, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Arm Intervention/treatment
No Intervention: non cannabis addict
30 non cannabis addict will be control group
Active Comparator: cannabis addict
30 cannabis addict will undergo rTMS
Device: rTMS
Repetitive transcranial magnetic stimulation (rTMS) will be done for cannabis addict

Primary Outcome Measures :
  1. Determination of role of rTMS for reducing cannabis craving [ Time Frame: 1 year ]
    Incidenc of cannabis craving after rTMS

Secondary Outcome Measures :
  1. Estimation of cortical excitability in cannabis addict [ Time Frame: 1 year ]
    Incidence of cannabis craving after cortical excitability

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 18to 50 years of age
  • cannabis use disorder according to DSM 5 definition
  • clear consent to participate in study

Exclusion Criteria:

  • cardiac peacemaker
  • metal implant in the head as participate will be applied to magnetic field of TMS
  • current intake of any medication affect cognition (as anti psychotic and anti epileptic)
  • current history of neurological , psychiatric or general medical disease .current or previous drug (other than cannabis )or alcohol abuse or participation in another trial during the past 8 weeks .
  • age younger than 18 and older than 50 years

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Responsible Party: Asmaa Omar Radwan Helal, Assiut University Identifier: NCT04106336     History of Changes
Other Study ID Numbers: rTMS in cannabis use disorder
First Posted: September 27, 2019    Key Record Dates
Last Update Posted: September 27, 2019
Last Verified: September 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Marijuana Abuse
Pathologic Processes
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders