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Cortical Excitability and Role of rTMS in Cannabis Use Disorder

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ClinicalTrials.gov Identifier: NCT04106336
Recruitment Status : Not yet recruiting
First Posted : September 27, 2019
Last Update Posted : September 27, 2019
Sponsor:
Information provided by (Responsible Party):
Asmaa Omar Radwan Helal, Assiut University

Brief Summary:
Repetitive transcranial magnetic stimulation (rTMS) and cortical excitability have a role in cannabis use disorder

Condition or disease Intervention/treatment Phase
Cannabis Use Disorder, Moderate Device: rTMS Early Phase 1

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cortical Excitability and Role of rTMS in Cannabis Use Disorder
Estimated Study Start Date : October 1, 2019
Estimated Primary Completion Date : October 1, 2020
Estimated Study Completion Date : December 30, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Arm Intervention/treatment
No Intervention: non cannabis addict
30 non cannabis addict will be control group
Active Comparator: cannabis addict
30 cannabis addict will undergo rTMS
Device: rTMS
Repetitive transcranial magnetic stimulation (rTMS) will be done for cannabis addict




Primary Outcome Measures :
  1. Determination of role of rTMS for reducing cannabis craving [ Time Frame: 1 year ]
    Incidenc of cannabis craving after rTMS


Secondary Outcome Measures :
  1. Estimation of cortical excitability in cannabis addict [ Time Frame: 1 year ]
    Incidence of cannabis craving after cortical excitability



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18to 50 years of age
  • cannabis use disorder according to DSM 5 definition
  • clear consent to participate in study

Exclusion Criteria:

  • cardiac peacemaker
  • metal implant in the head as participate will be applied to magnetic field of TMS
  • current intake of any medication affect cognition (as anti psychotic and anti epileptic)
  • current history of neurological , psychiatric or general medical disease .current or previous drug (other than cannabis )or alcohol abuse or participation in another trial during the past 8 weeks .
  • age younger than 18 and older than 50 years

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Responsible Party: Asmaa Omar Radwan Helal, Assiut University
ClinicalTrials.gov Identifier: NCT04106336     History of Changes
Other Study ID Numbers: rTMS in cannabis use disorder
First Posted: September 27, 2019    Key Record Dates
Last Update Posted: September 27, 2019
Last Verified: September 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Disease
Marijuana Abuse
Pathologic Processes
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders