Adolescent Attention to Emotion Study
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|ClinicalTrials.gov Identifier: NCT04105868|
Recruitment Status : Recruiting
First Posted : September 26, 2019
Last Update Posted : November 12, 2020
|Condition or disease||Intervention/treatment||Phase|
|Depression||Other: Neurofeedback||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||70 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression|
|Actual Study Start Date :||October 16, 2019|
|Estimated Primary Completion Date :||March 2024|
|Estimated Study Completion Date :||March 2024|
Participants will receive feedback about their attention to negative distractors during each trial using activity from their brain waves, which will help them reduce their attention to distractors.
Participants will receive feedback during a computerized task that is based on their own visuocortical activity evoked by attention to negative distractors and task-relevant stimuli on the computer screen.
- Change from baseline in affect-biased attention subsequently following neurofeedback (~1 hour) [ Time Frame: Baseline and following neurofeedback (~1 hour) ]To measure affect-biased attention, steady-state visual evoked potentials (SSVEPs) will be derived from EEG and will be used to index the amount of stimulus-driven attention to the negative distractors relative to goal-directed attention toward task-relevant stimuli. Larger SSVEPs indicate more attention to that stimulus. Affect-biased attention will be measured both before and after the real time SSVEP neurofeedback training to assess changes in affect-biased attention pre- to post-intervention.
- Change from baseline in sadness after laboratory stressor, which follows neurofeedback [ Time Frame: Baseline and following laboratory stressor (~30 minutes) ]Participants will complete a laboratory stressor following real time SSVEP neurofeedback training to assess how well it buffers sadness reactivity. To assess sadness reactivity, girls will report state sadness before and after the stressor using Visual Analog Scales. Participants will mark how they are feeling between neutral to very sad on a scale measuring 100 millimeters, with higher scores indicating greater state sadness.
- Change from baseline in anxiety after laboratory stressor, which follows neurofeedback [ Time Frame: Baseline and following laboratory stressor (~30 minutes) ]Participants will complete a laboratory stressor following real time SSVEP neurofeedback training to assess how well it buffers anxiety reactivity. To assess anxiety reactivity, girls will report state anxiety before and after the stressor using Visual Analog Scales.Participants will mark how they are feeling between neutral to very anxious on a scale measuring 100 millimeters, with higher scores indicating greater state anxiety.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04105868
|Contact: Mary Woody, PhDfirstname.lastname@example.org|
|Contact: Anna Wears, BSemail@example.com|
|United States, Pennsylvania|
|Western Psychiatric Institute and Clinic||Recruiting|
|Pittsburgh, Pennsylvania, United States, 15213|
|Contact: Mary Woody, Phd 412-648-6560|
|Principal Investigator:||Mary Woody, PhD||University of Pittsburgh|