A Non-Interventional Pilot Study to Explore the Skin Microbes in Skin Cancer
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The human Skin microbiome is a complex, interconnected web of microbes, living in a symbiotic relationship with their host. There are greater than ten times more bacteria on our bodies than there are human cells, all in a delicate and ever-changing balance to maintain a healthy skin microbiome. When this balance is disrupted, a condition known as dysbiosis, disease can occur. There is still a debate over whether dysbiosis is a cause of disease or a symptom of it. Naturally, since the microbiome has such a profound impact on human health, we want to study and learn as much about the microbiome as possible. By correlating this data with medical records for the patient's skin cancer, connections may begin to be drawn between organisms present in the microbiome of the skin microbiome, and skin cancer. Much like fingerprints, no microbiome is identical therefore the only chance we have at understanding disease is by looking at the skin microbiome and comparing the microorganisms on a patient with skin cancer biopsy and non-skin cancer biopsy.
Correlation of Skin Microbiome to Cancer via Relative Abundance Found in Microbiome Sequencing [ Time Frame: 1 year ]
Relative abundance of bacterial classes within taxonomic phyla and, more broadly, within their domain will be analyzed by sequencing the skin microbiome in both cancerous and non-cancerous areas. These data will then be compared to elucidate unique qualities of the microbiome in skin cancer.
Secondary Outcome Measures :
Validation of sequencing methods [ Time Frame: 1 year ]
To validate the sequencing methods used to generate microbiome data
Biospecimen Retention: Samples With DNA
Punch biopsies of skin from both cancerous and non-cancerous areas.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adults 18 and older with a diagnosis of skin cancer
Signed informed consent
18 years of age or older
Diagnosis of skin cancer, both melanoma and non-melanoma
Able/willing to have a skin punch biopsy in a non-cancerous location
Unable/unwilling to sign informed consent
Inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study.