Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
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|ClinicalTrials.gov Identifier: NCT04065893|
Recruitment Status : Not yet recruiting
First Posted : August 22, 2019
Last Update Posted : September 5, 2019
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.
Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.
|Condition or disease||Intervention/treatment|
|Systolic Heart Failure Ventricular Premature Complexes Ventricular Tachycardia Cardiac Resynchronization Therapy Reduced Biventricular Pacing||Procedure: Catheter ablation of ventricular arrhythmia Drug: Intensified medical therapy|
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Official Title:||Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy|
|Estimated Study Start Date :||September 2019|
|Estimated Primary Completion Date :||August 2020|
|Estimated Study Completion Date :||December 2020|
Catheter ablation group
Patients with reduced biventricular pacing due to PVC or VT receiving catheter ablation of PVC/VT according to guidelines and clinical practices
Procedure: Catheter ablation of ventricular arrhythmia
PVC or VT ablation
Medical treatment group
Patients with reduced biventricular pacing due to PVC or VT receiving intensified medical therapy (antiarrhythmics/betablocker) according to guidelines and clinical practices
Drug: Intensified medical therapy
Dosage increase / new onset of Betablocker / medical antiarrhythmic medication according to guideline and clinical practice
- Percentage of Biventricular pacing [ Time Frame: 3 month after intervention biventricular pacing (%) is routinely monitored ]Influence of intervention (Ablation/medical treatment) on previously reduced biventricular pacing percentage (<98%). Biventricular pacing is measured in percentage of stimulation and is monitored at routine device interrogation.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04065893
|Contact: Jakob Lüker, MDfirstname.lastname@example.org|
|Contact: Jan-Hendrik van den Bruck, MDemail@example.com|