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The WEstlake precision BIRTH cohort（WEBIRTH) is a prospective cohort study among women with hyperglycemia during pregnancy and their offspring living in Hangzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with hyperglycemia over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of WEBIRTH is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, low birth weight and small-for-gestational age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 week among the patients with the long-term metabolic health of the women and their offspring.
Condition or disease
Diabetes, GestationalPregnancy in DiabeticsIntrauterine Hyperglycemia
In China, an alarming increase in the prevalence of gestational diabetes mellitus (GDM)/ diabetes in pregnancy (DIP) patients has been observed in the past decade. GDM and DIP are of concern because they are associated with several maternal and fetal medical disorders. Lifestyle changes such as diet and physical activity modifications are key for the prevention and treatment of GDM/DIP. However, the associations between dietary intake and physical activity and health outcomes for GDM/DIP women and their children remain unclear due to subjective measurements of diet and physical activity. Recently, the development of objective measurement such as food image identification and wearable activity trackers give an opportunity to gain more precise insight into these associations. In addition, for the same food and physical activity exposure, GDM/DIP women may have different blood glucose responses, but the nature of variation is currently poorly characterized. Therefore, the present WEBIRTH design incorporates three unique components, 1) objective measurement of physical activity during pregnancy using accelerometer; 2) measurement of dietary intake using both FFQ and food photos; 3) measurement of blood glucose levels over 2 weeks using continuous glucose monitors, with a standardized test meal during the 2 weeks. We will then follow up these women participants during and after this pregnancy, and also follow up their offspring.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients who are diagnosed with GDM or DIP at 24-32 weeks of gestation will be recruited at the Hangzhou Women's Hospital, China.
Women aged 18 yrs or older
Women with GDM or DIP at 24-28 weeks of gestation
Women intended to deliver at Hangzhou Women's Hospital
Women intended to remain in Hangzhou with their child for ≥4 years
● Women with cancer and other serious medical disorders