The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose
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|ClinicalTrials.gov Identifier: NCT04057495|
Recruitment Status : Recruiting
First Posted : August 15, 2019
Last Update Posted : November 22, 2019
|Condition or disease||Intervention/treatment||Phase|
|Blood Pressure||Other: further fasting Other: white bread consumption Other: mango consumption||Not Applicable|
Cardiovascular disease (CVD) is the leading cause of mortality in the U.S, and aging is the largest risk factor for vascular diseases. Both male and female adults have increased risk for CVD as they age. For postmenopausal women, this risk is particularly elevated due to the loss of the protective effect of estrogen. It is evident that nutrition plays a crucial role in prevention of chronic diseases such as heart disease, stroke and cancer. Scientific evidence shows that high intake of plant-based food lowers the risk of CVD and many other chronic diseases.
Polyphenolic compounds in fruits and nuts have been the focus of extensive research regarding their potential to reduce risk for a number of chronic diseases. However, fruits and nuts vary largely in the type and amounts of phytonutrients they provide. Mango (Mangifera Idica L.), a commonly cultivated fruit worldwide, is rich in polyphenolic compounds such as gallic acid, mangiferin, quercetin glycosides, ferulic acid, and hydroxybenzoic acid. Many of those bioactive compounds have been found to have anti-diabetic and anti-inflammatory effects in cell models. For instance, mangiferin has been proved to effectively reducing glucose-induced endoplasmic reticulum stress by inhibiting IREα phosphorylation and ROS production in endothelial cells. However, it is unknown if the phytonutrients in mango will demonstrate a similar impact in humans. Therefore, the overall objective of this study is to investigate the effects of acute mango intake on blood pressure and blood glucose.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose|
|Actual Study Start Date :||November 11, 2019|
|Estimated Primary Completion Date :||June 1, 2020|
|Estimated Study Completion Date :||July 1, 2020|
Placebo Comparator: no mango intake
No mango consumption on the study visit
Other: further fasting
2 hours of fasting
Experimental: white bread with same amount of calorie as mango
White bread consumption on the study visit
Other: white bread consumption
113 grams of white bread consumption
Experimental: mango consumption
mango consumption on the study visit
Other: mango consumption
330 grams of mango consumption
- Change in blood pressure [ Time Frame: Baseline, 2 hours ]Changes in measures of blood pressure (mmHg) from baseline to two hours following fasting or consumption of white bread or mango.
- Change in blood glucose [ Time Frame: Baseline, 2 hours ]Changes in blood glucose from baseline to two hours following fasting or consumption of white bread or mango.
- Change in insulin levels [ Time Frame: Baseline, 2 hours ]Changes in insulin from baseline to two hours following fasting or consumption of white bread or mango.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04057495
|Contact: Robert Hackman, PhDemail@example.com|
|United States, California|
|Regal Human Nutrition Research Center||Recruiting|
|Davis, California, United States, 95616|
|Contact: Xiang Li 530-761-8971 firstname.lastname@example.org|