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Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa

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ClinicalTrials.gov Identifier: NCT04051879
Recruitment Status : Recruiting
First Posted : August 9, 2019
Last Update Posted : November 17, 2020
Sponsor:
Information provided by (Responsible Party):
Christina Wierenga, University of California, San Diego

Brief Summary:
The proposed study of adolescents with anorexia nervosa (AN) will examine the association of behavioral differences in constructs of decision making, brain structure and connectivity, and eating disorder (ED) symptoms. This study tests the novel hypothesis that goal-directed and habit learning for reward and punishment is altered in AN and is uniquely associated with divergent symptoms and differences in corticostriatal connectivity and microstructural integrity. We will recruit 78 females currently ill with AN and 26 controls ages 13-17 to investigate how goal-directed and habit learning for reward and punishment correspond to 1) clinical symptoms collected via interviews, self-report assessments, and ecological momentary assessment (EMA), and 2) brain structure and connectivity in the resting state. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Condition or disease
Anorexia Nervosa

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Study Type : Observational
Estimated Enrollment : 78 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa
Actual Study Start Date : April 1, 2019
Estimated Primary Completion Date : January 1, 2022
Estimated Study Completion Date : January 1, 2022

Group/Cohort
AN-R
Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa restricting subtype.
AN-BP
Participants that meet DSM-V criteria for Anorexia Nervosa binging/purging subtype.
Healthy Controls
Participants that do not meet DSM-V criteria for any disorder.



Primary Outcome Measures :
  1. Learning Task [ Time Frame: Computer Task (Baseline) ]
    A learning computer task will be used to dissociate model-based and model-free learning.

  2. Brain Function [ Time Frame: fMRI Scan (Baseline) ]
    Functional Magnetic Resonance Imaging will be used to correlate brain function with a weighting factor (ω), representing the relative balance between learning biases.



Information from the National Library of Medicine

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Ages Eligible for Study:   13 Years to 17 Years   (Child)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We will recruit from a clinical sample for the AN groups. We will recruit from a community sample for the healthy control group.
Criteria

Inclusion Criteria:

AN Group:

  • Between the ages of 13 and 17 years old
  • Meet DSM-V criteria for AN-R or AN-BP
  • Medically stable per American Academy of Pediatrics and the Society of Adolescent Medicine requirements, at least 75% adjusted ideal body weight, but still symptomatic as assessed by the Eating Disorders Examination and clinical report
  • Be at least 75% of adjusted ideal body weight

Healthy Control Group:

  • Between the ages of 13 and 17 years old

Exclusion Criteria:

All Groups:

  • Psychotic illness/other mental illness requiring hospitalization
  • Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures.
  • Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
  • Neurological disorder, neurodevelopmental disorder, or history of head injury with >30 min loss of consciousness
  • Any contraindication to undergoing an MRI
  • Primary obsessive compulsive disorder or primary major depressive disorder

Additional Exclusion Criteria for AN Group:

  • If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning

Additional Exclusion Criteria for Healthy Control Group:

  • Meet or met criteria for the diagnosis of any psychiatric disorder in their lifetime
  • Any history of binge eating or purging behaviors, including self-induced vomiting, laxative or diuretic misuse
  • Use of any psychoactive or other medication known to affect mood or concentration in the last 3 months
  • Have maintained 90% to 120% ideal body weight since menarche

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04051879


Contacts
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Contact: Christina Wierenga, PhD 858-534-8019 cwierenga@ucsd.edu

Locations
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United States, California
University of California, San Diego Recruiting
San Diego, California, United States, 92121
Contact: Leanna Diaz, MS    858-534-1064    lmdiaz@ucsd.edu   
Contact: Megan Martinho, BS    858-534-1064    mamartinho@ucsd.edu   
Sponsors and Collaborators
University of California, San Diego
Investigators
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Principal Investigator: Christina Wierenga, PhD University of California, San Diego
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Responsible Party: Christina Wierenga, Associate Professor, University of California, San Diego
ClinicalTrials.gov Identifier: NCT04051879    
Other Study ID Numbers: 182110
First Posted: August 9, 2019    Key Record Dates
Last Update Posted: November 17, 2020
Last Verified: November 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Anorexia
Anorexia Nervosa
Signs and Symptoms, Digestive
Feeding and Eating Disorders
Mental Disorders