Impedance Spectroscopy in Esophageal Cancer
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|ClinicalTrials.gov Identifier: NCT04046601|
Recruitment Status : Recruiting
First Posted : August 6, 2019
Last Update Posted : December 9, 2019
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection whereas advanced neoplasia might lead to an Operation of the esophagus. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and cancer can be sensed by electrical bioimpedance technique.
The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.
|Condition or disease||Intervention/treatment||Phase|
|Cancer of Esophagus||Device: impedance||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Observation group: patient who are planned for endoscopic resection because of known esophageal cancer. Immediately after retrieval the resected specimens will be investigated for their electrical impedance properties. The results of the impedance measurement are compared to the histological results.|
|Masking:||None (Open Label)|
|Masking Description:||no masking|
|Official Title:||Diagnosis of Early Barrett's Neoplasia and Esophageal Squamous Cell Neoplasia by Electrical Impedance Spectroscopy in Human Tissue|
|Actual Study Start Date :||October 9, 2019|
|Estimated Primary Completion Date :||December 31, 2019|
|Estimated Study Completion Date :||December 3, 2020|
every resected tissue will measured by an impedance probe
After endoscopic resection of early esophageal cancer, the tissue will be measured by an impedance probe between 10Hz-1000000Hz, 20mV. 8 gold electrodes have been integrated to the probe. The impedance will be measured in different ways between the elctrodes. There will be 10 measurements in total for each specimen.
- impedance [ Time Frame: 10 min ]value of 17 different frequencies in ohm
- differences in impedance [ Time Frame: 10 min ]Differences in electrical impedance properties between different stages of early esophageal cancer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04046601
|Contact: Mate Knabe, MD||00496984057249||MATE.KNABE@GOOGLEMAIL.COM|
|Contact: Sandra Blößeremail@example.com|
|Principal Investigator:||Mate Knabe, MD||Sana Klinikum Offenbach|