Predictors and Outcomes of Meropenem Treatment Failure Among Patients With Septic Shock in Intensive Care Unit (Meropenem)
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|ClinicalTrials.gov Identifier: NCT04042662|
Recruitment Status : Not yet recruiting
First Posted : August 2, 2019
Last Update Posted : August 2, 2019
Lately, the inappropriate used of Meropenem in critically ill patient were increased. Therefore, increased development of drug resistance bacteria towards Meropenem.
As known that Carbapenem-Resistance Enterobacteriaceae (CRE) is part of complication when Meropenem is widely used in the intensive care unit. CRE are very difficult to treat within Gram negative bacteria as it encodes Carbapenemase enzyme which breaks down Carbapenem anti-microbial such as Meropenem. The widespread carbapenemase production in the Enterobacteriaceae was unknown until the early 2000 until first reported in 2001. Despite that, most doctors and physician favourite, and still prescribe Meropenem as the antibiotic of choice for the critically ill patients empirically. This is because of its broad spectrum of coverage for bacteria. Thus, a number of Meropenem treatment failure were increased as resistance increase.This study will evaluate the appropriate use of Meropenem and determine the predictors of Meropenem treatment failure as well as the patient outcomes.As a result, it can be a guidance prior prescribing the Meropenem base on patient clinical condition and parameters while balancing the risk and benefits of its used.
|Condition or disease||Intervention/treatment|
|Predictors and Outcomes of Meropenem Treatment Failure||Other: no intervention|
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||Predictors and Outcomes of Meropenem Treatment Failure Among Patients With Septic Shock in Intensive Care Unit|
|Estimated Study Start Date :||August 5, 2019|
|Estimated Primary Completion Date :||August 5, 2020|
|Estimated Study Completion Date :||August 5, 2020|
|Meropenem Failure ( Treatment failure)||
Other: no intervention
|Meropenem Success ( Treatment Success)||
Other: no intervention
- Number of participants with treatment failure with antibiotic meropenem as assessed by clinical criteria of sepsis parameters among patient [ Time Frame: 3 years ]with septic shock in intensive care unit.
- Number of factors associated with antibiotic meropenem treatment failure among patient [ Time Frame: 3 years ]with septic shock in intensive care unit.
- Number of the patients who die after treated with antibiotic meropenem in intensive care unit [ Time Frame: 3 years ]Mortality