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rVA576 in Adult Mild to Moderate Bullous Pemphigoid Subjects

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ClinicalTrials.gov Identifier: NCT04035733
Recruitment Status : Recruiting
First Posted : July 29, 2019
Last Update Posted : July 29, 2019
Sponsor:
Information provided by (Responsible Party):
AKARI Therapeutics

Brief Summary:
Bullous pemphigoid (BP) is the most common of the autoimmune blistering skin diseases in Western Europe. [Joly 2012]The study will recruit the new onset or relapsing mild to moderate BP patients. The study population will consist of patients above the age of 18 years with an active episode of BP, confirmed by inclusion and exclusion criteria and who, in the opinion of the Investigator, would benefit from treatment with rVA576. Recombinant rVA576 is a small protein complement C5 and LTB4 inhibitor, which prevents the cleavage of C5 by C5 convertase and thereby inhibits generation of C5b-9 the membrane attack complex (MAC), as well as preventing the release of the anaphylatoxin C5a. rVA576 is effective in inhibiting terminal complement activity irrespective of the activating pathway (classical, lectin or alternative). This Phase IIa open-label single-arm study will evaluate the safety and efficacy of rVA576 in adult mild to moderate Bullous Pemphigoid patients

Condition or disease Intervention/treatment Phase
Bullous Pemphigoid (BP) Biological: rVA576 Phase 2

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 9 participants
Intervention Model: Single Group Assignment
Intervention Model Description: A Phase IIa open-label single arm study of safety and efficacy of rVA576 in adult mild to moderate Bullous Pemphigoid subjects
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase IIa Open-label Single Arm Study of Safety and Efficacy of rVA576 in Adult Mild to Moderate Bullous Pemphigoid Subjects
Actual Study Start Date : September 25, 2018
Estimated Primary Completion Date : September 19, 2019
Estimated Study Completion Date : October 19, 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pemphigus

Arm Intervention/treatment
Experimental: Open-label single arm study Biological: rVA576
BP subjects will be treated with 30 mg once daily rVA576 regime for 6 weeks.




Primary Outcome Measures :
  1. Safety parameter [ Time Frame: 42 days ]

    Proportion of participants reporting grade 3, 4 and 5 adverse events, which are related/possibly related to rVA576 during the treatment period.

    Treatment emergent adverse events (TEAEs) consist of:

    • Change from baseline in physical examination
    • ECG
    • Clinical laboratory tests
    • Vital signs The Common Terminology Criteria for Adverse Events (CTCAE v4.03) will be used to grade adverse events.


Secondary Outcome Measures :
  1. Efficacy Parameter [ Time Frame: 42 days ]
    Change in BPDAI between baseline (Day 1) and Day 42.

  2. Quality of life questionnaire [ Time Frame: 42 days ]
    Change in quality of life questionnaire between baseline (Day 1) and Day 42



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Adult male or female ≥18-year-old patients
  2. Subject with newly presenting mild to moderate cutaneous bullous pemphigoid (BP)
  3. BPDAI global score at the screening of 10-56 (≥ 10 but <56)
  4. Subjects with a relapse of mild to moderate bullous pemphigoid are eligible if their disease was quiescent for at least 2 months before the current relapse.
  5. Cutaneous bullous pemphigoid (BP) per standard diagnostic criteria:

    1. Clinical presentation (cutaneous blistering and/or itchy dermatosis), AND
    2. Direct immunofluorescence (DIF) studies.
  6. Karnofsky performance status >60%
  7. Adequate cardiac, renal, hepatic, neurological and psychiatric function as determined by the Investigator and demonstrated by screening laboratory evaluations, vital sign measurement, ECG recording and physical examination results.
  8. Women of childbearing potential (WOCBP) must agree to use effective contraception consistently throughout the study and have a negative serum pregnancy test at screening and a negative urine pregnancy test per the schedule of visits.
  9. Males with a childbearing potential partner must agree to use effective contraception consistently OR have had a vasectomy
  10. Willing and able to adhere to the study visit schedule and other protocol requirements including self-injection.
  11. Willing and able to provide voluntary written informed consent
  12. Willing to receive immunisation against Neisseria meningitidis and antibiotic prophylaxis in accordance with applicable guidelines and local standard of care of the PI at the trial site

Exclusion Criteria:

  1. Patients with severe BP. Severe disease to defined as global BPDAI ≥ 56.
  2. Patients with refractory BP.
  3. Suspected drug-induced BP
  4. Concomitant skin conditions preventing physical evaluation of BP.
  5. Participation in a clinical trial of an investigational product within 6 weeks of screening.
  6. Known hypersensitivity to tick or to rVA576 and any of its excipients.
  7. Treatment with biologics (e.g. etanercept, adalimumab, ustekinumab, infliximab, intravenous immunoglobulin (IVIG) and rituximab or other anti-CD20 therapies) within 5 half-lives of the drugs prior to screening.
  8. Known hypersensitivity to mometasone furoate or to other corticosteroids or to any excipients in mometasone furoate
  9. Received rVA576 for the treatment of the current episode of BP prior to study entry.
  10. Patients with severe medical or surgical conditions at screening or Day 1 including, but not limited to cardiac, respiratory, renal, hepatic, haematological, gastrointestinal, endocrine, pulmonary, cardiac, neurologic, cerebral, psychiatric, or any other severe acute or chronic medical condition that may increase the risk associated with study participation/treatment or may interfere with the interpretation of study results and, in the Investigator's opinion, would make the patient inappropriate for study entry.
  11. Presence of any malignancy that has been under active treatment or in previous 5 years except for patients with the removal of uncomplicated basal cell carcinoma or cutaneous squamous cell carcinoma, who may take part in the study.
  12. Congenital or acquired immunodeficiency (e.g. common variable immunodeficiency, organ transplantation).
  13. Clinically significant vital sign measurements or ECG findings as determined by the Investigator.
  14. Clinically significant abnormal laboratory test results.
  15. The active or recent history of clinically significant infection within 1 month of Screening.
  16. Pregnant or breast-feeding, or planning to become pregnant during the study.
  17. Evidence of an active disease of hepatitis B (HBsAg positive or HBcAg positive) or hepatitis C (HCV ab positive), CMV (IgM positive) or human immunodeficiency virus (HIV) infection (HIV1/2 Ab positive)
  18. Active abuse of alcohol or drugs.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04035733


Contacts
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Contact: Paulatsya Joshi, MD +44 7387107750 Paulatsya.Joshi@akaritx.com
Contact: Rohini Verma rohini@akaritx.com

Locations
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Germany
University of Lubeck Recruiting
Lubeck, Germany
Contact: Detlef Zillikens, Prof         
Netherlands
UMCG Groningen Recruiting
Groningen, Hanzeplein 1, Netherlands, 9700 RB
Contact: Barbara Horvath, MD    0031 50 361 2520    b.horvath@umcg.nl   
Sponsors and Collaborators
AKARI Therapeutics

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Responsible Party: AKARI Therapeutics
ClinicalTrials.gov Identifier: NCT04035733     History of Changes
Other Study ID Numbers: AK 801
First Posted: July 29, 2019    Key Record Dates
Last Update Posted: July 29, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Pemphigoid, Bullous
Skin Diseases, Vesiculobullous
Skin Diseases
Autoimmune Diseases
Immune System Diseases