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Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives

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ClinicalTrials.gov Identifier: NCT04004832
Recruitment Status : Not yet recruiting
First Posted : July 2, 2019
Last Update Posted : September 17, 2019
Sponsor:
Information provided by (Responsible Party):
Zeki Çetinkaya, TC Erciyes University

Brief Summary:
This study research the similarity of coronary artery lesions according to HLA tissue compatibility in fisrt degree relatives of the patients who just admitted clinic as Acute coronary syndrome and underwent angiyography before .

Condition or disease Intervention/treatment
Coronary Artery Disease With Myocardial Infarction Diagnostic Test: there is not any intervention procedure

Detailed Description:
Coronary artery disease (CAD), which is mainly caused by atherosclerosis, is the most prevalent illness and the leading cause of death worldwide. Increasing evidence suggests that inflammation plays a primordial role in atherogenesis and is closely associated with the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules. HLA genes are located in 6p21.3, the proteins encoded by these HLA genes have a major role to play in antigen presentation and inflammatory pathways. HLA involvement in inflammation is mainly associated with the HLA-dependent activation of T cells. studies reported that the susceptibility to CAD is related with the polymorphisms in HLA-DRB1. The above evidence indicates that the polymorphisms in HLA class II are associated with the risk of CAD . This study research investigate three objects , firstly what is the similarity of the coronary artery lesions according to the compatability of HLA alleles between the first degree relatives who went angiography before , secondly is there any relation between HLA subtype allels and the coronary artery (RCA ?LAD ? ,CX? and can such a relation be responsible from the lesions in this artery ,finally is there any relation between HLA subtypes and turkish race coronary artery disease

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Family-Based
Time Perspective: Other
Official Title: Comparison of the Severity and Prevalence of Coronary Atherosclerosis With Tissue Compliance (HLA Similarity ) in Patients Within First Degree Relatives
Estimated Study Start Date : November 19, 2019
Estimated Primary Completion Date : January 7, 2020
Estimated Study Completion Date : July 1, 2020

Resource links provided by the National Library of Medicine



Intervention Details:
  • Diagnostic Test: there is not any intervention procedure
    there is not any intervention procedure


Primary Outcome Measures :
  1. relation between HLA subgroups and severity and prevelance of coronary artery lesions [ Time Frame: 20 MAY 2019 - 30 MAY 2019 ]
    the hla similarity of two sibling patient %80 and the military syntax score %97,7


Biospecimen Retention:   Samples With DNA
blood sample


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
  • male or female with age between 18-70
  • hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before
Criteria

Inclusion Criteria:

  • male or female with age between 18-70
  • hospital admission due to acute coronary syndrome with first degree relative history who had coronary angiyography before

Exclusion Criteria:

  • first degree relative without any angiyography history before for patients who admitted as acute coronary syndrome

Publications:
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Responsible Party: Zeki Çetinkaya, Principal Investigator, TC Erciyes University
ClinicalTrials.gov Identifier: NCT04004832     History of Changes
Other Study ID Numbers: 2018/543
First Posted: July 2, 2019    Key Record Dates
Last Update Posted: September 17, 2019
Last Verified: September 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Myocardial Infarction
Atherosclerosis
Infarction
Ischemia
Pathologic Processes
Necrosis
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases