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selection and review of 50 cases of young patients with Giant Cell Tumor of bone. [ Time Frame: at baseline (Day0) ]
Investigators will review all the medical records, radiological imaging, and histological slides of all cases in order to collect the largest pediatric series.
Secondary Outcome Measures :
analysis of H3F3A mutation expression on tissue tumor material [ Time Frame: at baseline (Day0) ]
In all cases with enough available material, immunohistochemistry will be performed on tumor tissue material. Histone 3.3 (H3.3) genes, and H3F3A mutation will be analyzed with immunohistochemistry and/or by allele specific-PCR analysis in order to confirm that the lesions are a giant cell tumors of bone occurring in a non-canonic age group (skeletally immature patients).
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Layout table for eligibility information
Ages Eligible for Study:
up to 15 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
young patients with giant cell tumor of bone
Male and female patients under 15 years old treated at Rizzoli Institute from 01 January 1982 to 31 December 2018.
Diagnosis of giant cell tumor of bone, aneurysmatic bone cysts with solid features and giant cell reparative granuloma.
Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis
Written informed consent prior to any study-specific analysis and/or data collection
Patients with histological diagnosis different from diagnosis of giant cell tumor, aneurysmatic bone cysts with solid features, and giant cell reparative granuloma.
Patients with no available material for additional immunohistochemical and molecular analysis