Inferior Vena Cava (IVC) Diameters Before & After Interscalene Block
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ClinicalTrials.gov Identifier: NCT03989076
Recruitment Status :
(unable to enroll subjects)
First Posted : June 18, 2019
Last Update Posted : July 21, 2021
University of California, San Diego
Information provided by (Responsible Party):
Rodney Gabriel, University of California, San Diego
The purpose of this study is to understand how changes to breathing patterns in the chest affect blood flow to the heart from the inferior vena cava in the abdomen. Ultrasound of the upper abdomen will be used to visualize changes in breathing patterns in the chest and blood flow in the abdomen.
Condition or disease
IVC - Inferior Vena Cava Abnormality
Procedure: Interscalene Brachial Plexus Block
In recent practice, point-of-care ultrasound has been used to assess the size and respiratory variation of the inferior vena cava as a marker for volume status and fluid responsiveness. Little investigation has occurred regarding the mechanism of observed respiratory variation. Anesthetic plans for surgery (e.g. shoulder replacement) frequently employ interscalene injections to target and block the brachial plexus, which (on the same side) results in phrenic nerve palsy and paralysis of the diaphragm. The goal of this study is to examine the relationship between diaphragmatic function and variation in IVC diameter. Specifically, the investigators will evaluate and compare the size and variability of the inferior vena cava by point-of-care ultrasound before and after brachial plexus block.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult (age > 18 years) patients undergoing surgery of any type at UC San Diego Medical Center for whom the surgeon has requested an interscalene nerve block and for whom the block is clinically indicated as determined by the primary anesthesiologist.
Adult (age > 18 years)
Scheduled to receive an interscalene block
Any person with known, pre-existing phrenic nerve, diaphragmatic, or inferior vena cava anomaly.
Patients who cannot be successfully imaged by ultrasound or who cannot participate in spirometry will additionally be excluded.
Non-English speaking patients will be excluded as well as there is no research funding to translate consent forms. Given that there is no potential benefit to participation in the study, this does not exclude these individuals from any potentially beneficial therapy.