Dual-benefits of Aerobic and Resistance Training (DART)
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|ClinicalTrials.gov Identifier: NCT03978572|
Recruitment Status : Suspended (Temporarily paused due to COVID-19 and expected to resume. Not of IRB approval)
First Posted : June 7, 2019
Last Update Posted : April 27, 2020
|Condition or disease||Intervention/treatment||Phase|
|Sarcopenia Aging Disability Physical||Behavioral: Resistance Training Behavioral: Moderate-Intensity Continuous Cycling Behavioral: High-Intensity Interval Cycling||Not Applicable|
This project is confronting age-related physical disability by optimizing exercise strategies for older adults. Aerobic training is recommended to improve cardiorespiratory (heart and lung) function, while strength training is recommended for muscular function. These exercise effects are necessary for building healthier lives and reducing mortality and disability risk, but most older adults who do exercise typically only perform one type of exercise. In doing so they are missing a key component for healthy aging. This study will address whether stationary-cycling high-intensity interval training results in both cardiorespiratory and muscular improvements, and it will be the first controlled study comparing adaptations to high-intensity interval, aerobic, and strength training in sedentary older adults.
It is unclear whether the lack of muscular adaptations to traditional aerobic training is due to the low intensity/high volume model that is currently prescribed, and thus the central hypothesize of the study is that stationary-cycling high-intensity interval training can improve both cardiorespiratory and muscular function. To test this hypothesis, the investigators will measure heart, lung, and muscle function, as well as physical performance in sedentary older adults, before and after 12 weeks of supervised training using one of three exercise strategies; stationary-cycling high-intensity interval training, stationary-cycling moderate-intensity continuous training, or strength training. By comparing the outcomes across these three groups, the investigators will be able to confirm if short intervals of high-intensity exercise can elicit both cardiorespiratory and muscular benefits.
This work will demonstrate that older adults can improve their cardiovascular health and muscular strength with a single exercise strategy. Establishing in detail the cardiovascular and muscular benefits of this exercise can lead to the implementation of new and improved exercise guidelines for cardiovascular health and reduced physical disability in older adults. Incidentally, it will also provide a framework for future studies to investigate the importance of intensity in exercise. At the end of this study the investigators will be able to disseminate a new evidence-based exercise protocol that will address a significant barrier to healthy aging.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||The DART Study: Exercise Strategies to Improve Physical Function in Older Adults|
|Actual Study Start Date :||February 1, 2019|
|Estimated Primary Completion Date :||September 30, 2020|
|Estimated Study Completion Date :||September 30, 2020|
Active Comparator: Resistance Training
12 weeks of whole-body progressive resistance training, three days per week, lower-extremity focused (60% of exercises targeting lower extremities)
Behavioral: Resistance Training
Exercise intervention designed to improve muscular strength and power
Active Comparator: Moderate-intensity continuous cycling
12 weeks of progressive endurance cycling on a stationary bicycle at a target heart rate, three days per week.
Behavioral: Moderate-Intensity Continuous Cycling
Exercise intervention designed to improve cardiorespiratory fitness and muscular endurance
Experimental: High-intensity interval cycling
12 weeks of progressive high-intensity interval cycling on a stationary bicycle, three days per week.
Behavioral: High-Intensity Interval Cycling
Exercise intervention designed to improve cardiorespiratory fitness, muscular endurance, and muscular strength and power
- Maximal Oxygen Consumption [ Time Frame: Change from baseline at 12 weeks ]The primary endpoint is maximal oxygen consumption measured by both relative and absolute changes in maximal oxygen consumption obtained during a graded exercise test on a cycle ergometer.
- Knee extensor isokinetic power [ Time Frame: Change from baseline at 12 weeks ]Maximal muscle power (maximal torque in foot-pounds) of the quadriceps using an isokinetic dynamometer
- Knee extensor isometric force production [ Time Frame: Change from baseline at 12 weeks ]Maximal muscle strength of the quadriceps (in foot-pounds) as measured by an isometric dynamometer
- Knee extensor isokinetic endurance [ Time Frame: Change from baseline at 12 weeks ]Total power output (cumulative torque in foot-pounds) produced from 120 consecutive maximal knee extensions using an isokinetic dynamometer
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03978572
|United States, Ohio|
|Athens, Ohio, United States, 45701|
|Study Chair:||Brian C Clark, PhD||Ohio University|