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Efficacy of Olaparib in Advanced Cancers Occurring in Patients With Germline Mutations or Somatic Tumor Mutations in Homologous Recombination Genes (1-2018 BSMO)

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ClinicalTrials.gov Identifier: NCT03967938
Recruitment Status : Recruiting
First Posted : May 30, 2019
Last Update Posted : July 9, 2020
Kom Op Tegen Kanker
Information provided by (Responsible Party):
Dr. Sofie Joris, AZ-VUB

Brief Summary:
At present targeted therapy with the PARP inhibitor olaparib has become standard of care in advanced platinum sensitive BRCA1/2 mutant ovarian cancer. The key in this sensitivity is the loss of homologous recombination (HR) function. The current project aims to treat patients with any type of cancer carrying in their germline a mutation in genes that generate such an homologous recombination deficiency (HRD) or have an acquired somatic mutation in their tumor with the targeted PARP inhibitor olaparib. The project would thus bring access to a targeted drug matched to the genomic profile of the tumor of these patients and provide oncologists with information regarding efficacy and safety of olaparib in these patients. This evidence could then later lead to a more routine regulatory access.

Condition or disease Intervention/treatment Phase
Advanced Cancers Harbouring Mutations in HRG Drug: Olaparib Oral Capsule Phase 2

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 540 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Efficacy of Olaparib in Advanced Cancers Occurring in Patients With Germline Mutations or Somatic Tumor Mutations in Homologous Recombination Genes
Actual Study Start Date : February 7, 2019
Estimated Primary Completion Date : December 31, 2023
Estimated Study Completion Date : December 31, 2024

Resource links provided by the National Library of Medicine

Drug Information available for: Olaparib

Arm Intervention/treatment
Experimental: Olaparib
tablets of 300mg twice daily until disease progression
Drug: Olaparib Oral Capsule
Olaparib tablets 300mg twice daily

Primary Outcome Measures :
  1. Response rate according to RECIST 1.1 [ Time Frame: every 2 months from date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months ]
    The primary analysis will estimate the proportion of patients who achieve confirmed objective response according to the RECIST criteria. Objective response is defined as confirmed CR or PR.

  2. Response duration according to RECIST 1.1 [ Time Frame: from date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months ]
    Patients whose best RECIST assessment is stable disease, partial, or complete response will be considered to have achieved disease control. Descriptive statistics will be produced for the duration of confirmed objective response and disease control.

Secondary Outcome Measures :
  1. locus-specific LOH [ Time Frame: through study completion, an average of 1 year ]
    Correlate efficacy with locus-specific LOH in the tumors in case of cancers atypical for the germline mutations

  2. PFS [ Time Frame: every 2 months from date of randomization until teh date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months. ]
    PFS is the time from start of treatment until the occurrence of disease progression or death, whichever comes first. Date of progression is the earliest of (1) date of imaging showing disease progression, or (2) date of investigator assessment of clinical progression, or (3) date recorded from post study follow-up for disease progression, or (4) start of new anti-cancer treatment (i.e., either the secondary treatment regimen or other anti-cancer treatment).

  3. OS [ Time Frame: every 2 months from date of randomization until teh date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months. ]
    OS is the time from start of treatment until death, for whatever reason.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Provision of informed consent prior to any study specific procedures
  2. Female or male aged > 18 years
  3. Histologically proven advanced cancer, either locally or metastatic, harboring a specific pathogenic genetic alteration (with the exception of breast, pancreas, or prostate cancer patients harboring a BRCA1/2 mutation and HRD ovarian cancer)
  4. No approved targeted therapy for the specific genetic alteration in the specific tumor type
  5. No other genomic driven phase I, II or III trial available for the specific genomic alteration in the specific tumor type
  6. Available tumor tissue for verification of the mutation by Sanger sequencing.
  7. Patients must have normal organ and bone marrow function measured within 28 days prior to administration of study treatment.
  8. Eastern Cooperative Oncology Group (ECOG) performance status 0-1
  9. Patients must have a life expectancy ≥16 weeks
  10. Postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within 28 days of study treatment and confirmed prior to treatment on day 1.
  11. Patients are willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations.
  12. At least one lesion (measurable and/or non-measurable) that can be accurately assessed at baseline by CT and is suitable for repeated assessment.
  13. *Formalin fixed, paraffin embedded (FFPE) tumour sample from the primary cancer must be available for local genetic testing.

Exclusion Criteria:

  1. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site)
  2. Ovarian cancer patients harboring a HRD and breast, prostate and pancreas cancer patients who carry a BRCA1/2 mutation
  3. Previous enrolment in the present study
  4. Participation in another clinical study with an investigational product during the last 4 weeks or radiotherapy (except for palliative reasons) within three weeks prior to study treatment.
  5. History of non-compliance to medical regimens
  6. Any previous treatment with PARP inhibitor, including olaparib.
  7. Other malignancy within the last 5 years except: adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS), Stage 1, grade 1 endometrial carcinoma, or other solid tumours including lymphomas (without bone marrow involvement) curatively treated with no evidence of disease for ≥5 years. Patients with a history of localized triple negative breast cancer may be eligible, provided they completed their adjuvant chemotherapy more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease
  8. Resting ECG with QTc > 470 msec on 2 or more time points within a 24 hour period or indicating uncontrolled, potentially reversible cardiac conditions as judged by the investigator (er., unstable ischemia, uncontrolled symptomatic arrhythmia, congestive heart failure, QTcF prolongation >500ms, electrolyte disturbances, etc.) or patients with congenital long QT syndrome
  9. Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within four weeks prior to study treatment. Patients must have recovered from radiotherapy toxicities prior to enrollment.
  10. Concomitant use of known strong CYP3A inhibitors (eg. itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (eg. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting olaparib is 2 weeks.
  11. Concomitant use of known strong (eg. phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort ) or moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required washout period prior to starting olaparib is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents.
  12. Persistent toxicities (Common Terminology Criteria for Adverse Event (CTCAE) > grade 2) caused by previous cancer therapy, excluding alopecia.
  13. Patients with myelodysplastic syndrome/acute myeloid leukaemia or with features suggestive of MDS/AML.
  14. Patients with symptomatic uncontrolled brain metastases. A scan to confirm the absence of brain metastases is not required. The patient can receive a stable dose of corticosteroids before and during the study as long as these were started at least 4 weeks prior to treatment. Patients with spinal cord compression unless considered to have received definitive treatment for this and evidence of clinically stable disease for 28 days.
  15. Major surgery within 2 weeks of starting study treatment and patients must have recovered from any effects of any major surgery.
  16. Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3 months) myocardial infarction, uncontrolled major seizure disorder, unstable spinal cord compression, superior vena cava syndrome, extensive interstitial bilateral lung disease on High Resolution Computed Tomography (HRCT) scan or any psychiatric disorder that prohibits obtaining informed consent.
  17. Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the study medication.
  18. Breast feeding women. (delete if male population)
  19. Immunocompromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV).
  20. Patients with a known hypersensitivity to olaparib or any of the excipients of the product.
  21. Patients with known active hepatitis (i.e. Hepatitis B or C) due to risk of transmitting the infection through blood or other body fluids
  22. Previous allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT)
  23. Whole blood transfusions in the last 120 days prior to entry to the study (packed red blood cells and platelet transfusions are acceptable, for timing refer to inclusion criteria no.3)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03967938

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Contact: Sofie Joris, Dr +32 2 477 64 15 sofie.joris@uzbrussel.be

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UZ Brussel Recruiting
Brussels, Belgium, 1090
Contact: Sofie Joris, Dr    +32 2 477 64 15    sofie.joris@uzbrussel.be   
Principal Investigator: sofie Joris, Dr         
Sub-Investigator: Lore Decoster, Dr         
Sub-Investigator: Christel Fontaine, Dr         
Sub-Investigator: Sandrine Aspeslagh, Dr         
Sub-Investigator: Bart Neyns, Dr         
Sponsors and Collaborators
Kom Op Tegen Kanker
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Principal Investigator: Sofie Joris, Dr Universitair Ziekenhuis Brussel
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Responsible Party: Dr. Sofie Joris, Coordinator Investigator, AZ-VUB
ClinicalTrials.gov Identifier: NCT03967938    
Other Study ID Numbers: Precision 2 - Olaparib
First Posted: May 30, 2019    Key Record Dates
Last Update Posted: July 9, 2020
Last Verified: July 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No
Additional relevant MeSH terms:
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Poly(ADP-ribose) Polymerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents