Working... Menu

Effect of Cholesterol Level on Postoperative Acute Kidney Injury of Non-cardiac Surgeries

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03954353
Recruitment Status : Recruiting
First Posted : May 17, 2019
Last Update Posted : May 24, 2019
Information provided by (Responsible Party):
Yan Zhou, MD, Peking University First Hospital

Brief Summary:
Preoperative serum cholesterol level may influence occurrence of postoperative acute kidney injury of cardiac surgeries. However, the effect of Preoperative serum cholesterol level for non cardiac surgery remains unknown. This study aimed to explore the effect in non-cardiac surgical population.

Condition or disease
Acute Kidney Injury

Layout table for study information
Study Type : Observational
Estimated Enrollment : 70000 participants
Observational Model: Other
Time Perspective: Retrospective
Official Title: Effect of Cholesterol Level on Postoperative Acute Kidney Injury of Non-cardiac Surgeries
Actual Study Start Date : May 17, 2019
Estimated Primary Completion Date : June 5, 2019
Estimated Study Completion Date : June 6, 2019

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. post-operative acute kidney injury within 30 days in the hospital [ Time Frame: 30 days postoperatively in hospital ]
    It was defined by patient's postoperative serum creatine increase no less than 26.5 μmol/l within 48 hours, or 1.5 times from baseline within the 7 days after surgery or initializing blood dialysis.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
adults (age ≥ 18 years old) who underwent elective non-cardiac surgery from January 1, 2012, to December 31, 2017.

Inclusion Criteria:

adults elective non-cardiac surgery

Exclusion Criteria:

cardiac surgeries kidney surgeries obstetric surgeries local infiltration anesthesia perioperative data missing

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03954353

Layout table for location contacts
Contact: Yan Zhou, MD, PhD 13641202040

Layout table for location information
China, Beijing
First hospital Peking University Recruiting
Beijing, Beijing, China, 100034
Contact: Yan Zhou, doctor    13641202040   
Sponsors and Collaborators
Peking University First Hospital

Layout table for additonal information
Responsible Party: Yan Zhou, MD, Principal Investigator, Peking University First Hospital Identifier: NCT03954353     History of Changes
Other Study ID Numbers: ECAKI
First Posted: May 17, 2019    Key Record Dates
Last Update Posted: May 24, 2019
Last Verified: May 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Layout table for MeSH terms
Wounds and Injuries
Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases