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The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD

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ClinicalTrials.gov Identifier: NCT03950531
Recruitment Status : Completed
First Posted : May 15, 2019
Last Update Posted : May 17, 2019
Sponsor:
Information provided by (Responsible Party):
Zeynep FENDOGLU, Ministry of Health, Turkey

Brief Summary:
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.

Condition or disease Intervention/treatment
Bronchiectasis Chronic Obstructive Pulmonary Disease Other: No intervention

Detailed Description:
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. COPD exacerbations are characterized by worsening of dyspnea, coughing and expectoration. Exacerbations requiring hospitalization are the main cause of morbidity and mortality in COPD. Bronchiectasis is the irreversible extension of the bronchi. Usually follows with chronic sputum cough, airway obstruction and recurrent infection episodes. The association of bronchiectasis and COPD has long been known and its incidence is in the range of 30-50%. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.

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Study Type : Observational
Actual Enrollment : 122 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Effect of Bronchiectasis on the Exacerbation and Mortality of Chronic Obstructive Pulmonary Disease
Actual Study Start Date : January 25, 2010
Actual Primary Completion Date : December 25, 2014
Actual Study Completion Date : January 25, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases

Group/Cohort Intervention/treatment
COPD exacerbation without Bronchiectasis
COPD patients who have been in exacerbation period and have no bronchiectasis
Other: No intervention
COPD exacerbation with Bronchiectasis
COPD patients who have been in exacerbation period and have bronchiectasis
Other: No intervention



Primary Outcome Measures :
  1. Charlson Comorbidity Index [ Time Frame: 1 hour ]
    Comorbidity scores


Secondary Outcome Measures :
  1. Spirometry [ Time Frame: 1 hour ]
    Pulmonary function measurement



Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patient with COPD exacerbation
Criteria

Inclusion Criteria:

  • Patients who underwent thoracic tomography in the last year according to index exacerbation date were included in the study

Exclusion Criteria:

  • Cases that mimic COPD exacerbation (pneumonia, pulmonary thromboembolism, pulmonary congestion, pneumothorax, pleural effusion, lung malignancy, asthma, asthma-COPD overlap syndrome) and patients admitted to the intensive care unit were excluded from the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03950531


Sponsors and Collaborators
Ministry of Health, Turkey
Investigators
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Study Chair: Nurdan Kokturk, Professor Gazi University Faculty of Medicine

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Responsible Party: Zeynep FENDOGLU, Principal investigator, Ministry of Health, Turkey
ClinicalTrials.gov Identifier: NCT03950531     History of Changes
Other Study ID Numbers: 123678
First Posted: May 15, 2019    Key Record Dates
Last Update Posted: May 17, 2019
Last Verified: May 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Zeynep FENDOGLU, Ministry of Health, Turkey:
Bronchiectasis
Chronic Obstructive Pulmonary Disease
Exacerbation
Computed Tomography

Additional relevant MeSH terms:
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Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Bronchiectasis
Respiratory Tract Diseases
Bronchial Diseases