Treatment of Advanced Intrahepatic Cholangiocarcinoma (TAICC)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT03940378 |
Recruitment Status :
Recruiting
First Posted : May 7, 2019
Last Update Posted : May 7, 2019
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
ICC | Drug: Levamisole Hydrochloride Drug: Anlotinib Hydrochloride Capsules | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 152 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | The Efficacy of Levamisole Hcl in Advanced Intrahepatic Cholangiocarcinoma . A Multicenter, Open, Randomized, Prospective Study |
Actual Study Start Date : | February 1, 2019 |
Estimated Primary Completion Date : | February 1, 2023 |
Estimated Study Completion Date : | February 1, 2023 |

Arm | Intervention/treatment |
---|---|
Experimental: One-drug Regimes
Basic drug : Anlotinib Hydrochloride Capsules
|
Drug: Anlotinib Hydrochloride Capsules
Anlotinib Hydrochloride Capsules Anlotinib Hydrochloride Capsules 12mg / capsule; 12mg/d; po;
Other Name: AHC |
Experimental: Two-Drug Regimens
Basic drug: Anlotinib Hydrochloride Capsules Add Intervention drug: Levamisole Hydrochloride
|
Drug: Levamisole Hydrochloride
Levamisole Hydrochloride Levamisole Hydrochloride 25mg/tablet; 150mg/d; po;
Other Name: LH Drug: Anlotinib Hydrochloride Capsules Anlotinib Hydrochloride Capsules Anlotinib Hydrochloride Capsules 12mg / capsule; 12mg/d; po;
Other Name: AHC |
- Progression-free Survival [ Time Frame: 24 months ]Time from start of treatment until the first documented event of symptomatic progression or death.
- Overall Survival [ Time Frame: 48 months ]Time from start of treatment to death from any cause, or last known date of survival
- Disease Control Rate (DCR) [ Time Frame: 28 days ]the percentage of patients with advanced or metastatic cancer who have achieved complete response, partial response and stable disease
- Objective Response Rate(ORR) [ Time Frame: 28 days ]Proportion of patients with reduction in tumor burden of a predefined amount
- The change of AFP biomarker [ Time Frame: approximately 24 months ]Concentration of AFP biomarker change in tumor markers

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- 1. Ages 18-65 years
- 2. The diagnosis of ICC: in accordance with "diagnostic and treating standards on primary liver cancer" or histological/cytological diagnosis of primary liver cancer
- 3. Un-resectable HCC : patients with developing primary liver cancer of Barcelona stage(BCLC) B; multiple nodules (less than 5, the total diameter of less than 20 cm), no invasion, no symptoms;refusing open surgical treatment and volunteering for the treatment
- 4. The First-line system therapy failure (or residual lesion) from the group of this study a signed informed consent (time) for 2 weeks or more basic returned to normal and adverse events (NCI CTCAE Ⅰ level or less);
- 5. Child-Pugh liver function class A/B(score: ≤7)
- 6. Performance status 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) scale in one week before admission
- 7. Estimated survival time > 3 months
- 8. HBV DNA#2000 IU/ml#10^4 copies/ml); or HBV DNA≥2000 IU/ml and are accepting effective antiviral therapy
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9. The major organ function is normal. that is meeting the following standards:
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Blood routine examination: (No blood transfusion, no G-CSF and no medication were corrected within 14 days before screening)
a.HB≥80g/L# b.ANC≥1.5×109/L#c.PLT≥50×109/L#
-
Biochemical examination: (ALB was not transfused within 14 days before screening) a.ALB ≥29 g/L# b.ALT#AST<5ULN#c.TBIL ≤3ULN#d.creatinine
- 1.5ULN( albumin and bilirubin, two indicators of Child-Pugh liver function class, can only have one for 2 points)
-
- 10. For women of childbearing age, the results of serum/urine pregnancy tests must be negative within 7 days before initiation of treatment. All men and women who participate in the study have to take reliable contraceptive measures within the trial and eight weeks after the trial is completed
- 11. volunteers must signed informed consent
Exclusion Criteria:
- 1. With a history of alimentary tract hemorrhage or a definite tendency of gastrointestinal bleeding, such as varices of fundus of stomach and esophagus with bleeding risk; local active ulcer lesions; fecal occult blood ≥#++#
- 2. Patients with hepatobiliary cell carcinoma, mixed cell carcinoma or lamellar cell carcinoma; in the past (within 5 years) or at the same time suffering from other untreated malignant tumors; excluding cured basal cell carcinoma and carcinoma in situs of cervix
- 3. Patients who are undergoing liver transplantation or have a history of organ transplantation(excluding the patient who has undergone liver transplantation before)
- 4. Patients with an allergic history of Levamisole Hydrochloride and Anlotinib Hydrochloride Capsules
- 5. The blood pressure can not be reduced to the normal range by the antihypertensive drug treatment in patients with hypertension(systolic pressure#140 mmHg, diastolic pressure#90 mmHg)
- 6. Patients with myocardial ischemia or myocardial infarction over grade II or a poorly controlled arrhythmia (including QTc interval: men ≥ 450 ms; women ≥ 470 ms)
- 7. Cardiac functional insufficiency of grade III to IV according to NYHA standard; echocardiography: LVEF#50%
- 8. Many factors that influence oral medication, such as unable to swallow; chronic diarrhea; intestinal obstruction; the situations which significantly affect the use and absorption of drugs
- 9. Abdominal fistula, gastrointestinal perforation, or abdominal abscess occurred within 28 days before participating the study
- 10. Dysfunction of blood coagulation(INR#2.0 or PT# 16s#APTT > 43s#TT > 21s#Fbg < 2g/L), having a tendency to bleed or undergoing thrombolysis or anticoagulant therapy; ascites with clinical symptoms, that is requiring therapeutic abdominal paracentesis or drainage or Child-Pugh score ≥2
- 11. Objective evidence of pulmonary fibrosis history, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug associated pneumonia, and severe lung function impairment in the past and at present
- 12. Urine routine showed that urine protein ≥++ or the urine protein in 24 hours#1.0 g
- 13. Patients who have been treated with potent CYP3A4 inhibitors (ketoconazole, itraconazole, voriconazole, ritonavir, clarithromycin, telithromycin, troleandomycin, erythromycin, cimetidine and so on) within 28 days before participating the study, or potent CYP3A4 inducers (dexamethasone, phenytoin, rifampin, rifabutin, carbamazepine, phenobarbitone and so on) within 12 days before participating the study.
- 14. Pregnant or lactating women; fertile patients who are unwilling or unable to adopt effective contraceptives
- 15. Patients with mental sickness or the history of psychotropic drug abuse
- 16. Patients with severe infection (unable to control the infection effectively)
- 17. The treatment history affecting this program or its efficacy, such as stem cell transplantation, immune regulation (including PD-1 and other test regimens) recently (within half a year)
- 18. The researchers believe that any other factors unsuitable for entering into the study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03940378
Contact: Zujiang Yu, pro | 0086-0371-67966942 | johnyuem@zzu.edu.cn |
China, Henan | |
The First Affiliated Hospital of Zhengzhou University | Recruiting |
Zhengzhou, Henan, China, 450000 | |
Contact: Zujiang Yu, pro 0086-0371-67966942 johnyuem@zzu.edu.cn | |
Contact: Juan Li, pro 0086-0371-67966942 ananli1984@126.com |
Principal Investigator: | Zujiang Yu | The First Affiliated Hospital of Zhengzhou University |
Responsible Party: | Zujiang YU, The director of infectious diseases department, The First Affiliated Hospital of Zhengzhou University |
ClinicalTrials.gov Identifier: | NCT03940378 |
Other Study ID Numbers: |
LEVICC-001 |
First Posted: | May 7, 2019 Key Record Dates |
Last Update Posted: | May 7, 2019 |
Last Verified: | May 2019 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Cholangiocarcinoma Adenocarcinoma Carcinoma Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Levamisole Adjuvants, Immunologic |
Immunologic Factors Physiological Effects of Drugs Antinematodal Agents Anthelmintics Antiparasitic Agents Anti-Infective Agents Antirheumatic Agents |