Conventional Ovarian Stimulation vs. Single Injection Stimulation of Corifollitropin Alfa in Oocyte Donor (TAIL)
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|ClinicalTrials.gov Identifier: NCT03939403|
Recruitment Status : Recruiting
First Posted : May 6, 2019
Last Update Posted : June 23, 2020
This study aims to study the efficiency of using a single injection of Corifollitropin alfa for ovarian stimulation by initiating administration late and without further administration of follicle-stimulating hormone after the 7th day of stimulation compared to conventional ovarian stimulation using Corifollitropin alfa (drug administration 5 days after cessation of hormonal contraceptive and supplementation with follicle-stimulating hormone daily administration from the 8th day of stimulation).
This a controlled randomized clinical study and 180 patients will be recruited (90 per arm) and the primary study outcome is the number of obtained oocytes.
|Condition or disease||Intervention/treatment||Phase|
|Ovarian Stimulation||Drug: Time of administration of Corifollitropin Alfa||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||180 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Conventional Ovarian Stimulation vs. Single Injection Stimulation of Corifollitropin Alfa in Oocyte Donor. A Randomized Clinical Trial. TAIL Study|
|Actual Study Start Date :||November 18, 2019|
|Estimated Primary Completion Date :||August 1, 2020|
|Estimated Study Completion Date :||November 1, 2020|
|Experimental: 7-days pill free interval||
Drug: Time of administration of Corifollitropin Alfa
The used treatment will be identical in both arms. The difference between the groups will be the moment of beginning of the stimulation as well as the later administration of more FSH activity.
The control grup will receive the treatment on the 5th day after the cessation of hormonal contraceptive use. The used treatment will be identical in both arms. The difference between the groups will be the moment of beginning of the stimulation as well as the later administration of more FSH activity.
The intervention grup will receive the treatment on the 7th day after the cessation of hormonal contraceptive use.
|No Intervention: 5-days pill free interval|
- Number of oocytes [ Time Frame: At the end of stimulation ]Number of oocytes after stimulation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03939403
|Contact: Anna Pitasfirstname.lastname@example.org|
|Alicante, Spain, 03016|