Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicty
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|ClinicalTrials.gov Identifier: NCT03921099|
Recruitment Status : Recruiting
First Posted : April 19, 2019
Last Update Posted : April 19, 2019
|Condition or disease||Intervention/treatment||Phase|
|Acute Kidney Injury||Drug: Ascorbic Acid||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Official Title:||Evaluation of the Impact of Ascorbic Acid in the Prevention of Vancomycin Induced Nephrotoxicity|
|Actual Study Start Date :||January 17, 2019|
|Estimated Primary Completion Date :||August 2019|
|Estimated Study Completion Date :||October 2019|
No Intervention: Vancomycin only
Vancomycin 15-20mg/kg intravenous every 8-12 hours.
Experimental: Vancomycin +Ascorbic acid
Vancomycin 15-20mg/kg intravenous every 8-12 hours. Ascorbic acid 1gm every 12 hours orally just before vancomycin by half an hour for seven days.
Drug: Ascorbic Acid
ascorbic acid is an antioxidant that is expected to prevent nephrotoxicty induced by Vancomycin.
- Incidence of nephrotoxicty [ Time Frame: one week ]Incidence of nephrotoxicty will be described according to RIFLE criteria
- 28 days Mortality [ Time Frame: one month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03921099
|Contact: Nouran Elsherazy, Bachelor||+201224959630||Nouran_elsherazy@yahoo.com|
|Contact: Naglaa Bazan, PhD||NaglaaBazan@yahoo.com|
|Cairo university hospitals||Recruiting|
|Cairo, Egypt, 11562|
|Contact: Critical care department Cairo university Hopsitals|