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Effect of Chronic Arsenic Exposure on Malnutrition of Under Five Children

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ClinicalTrials.gov Identifier: NCT03893721
Recruitment Status : Not yet recruiting
First Posted : March 28, 2019
Last Update Posted : March 28, 2019
Sponsor:
Information provided by (Responsible Party):
alyaa abdelaal mohamed abdelaal, Assiut University

Brief Summary:
Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z score less than -2 standard deviation of World Health Organization median. Wasting is weight -for- height Z score less than -2 standard deviation of World Health Organization median.

Condition or disease Intervention/treatment
Malnutrition, Child Arsenic Poisoning Chronic Diagnostic Test: arsenic exposure

Detailed Description:

prevalence of under-five stunting, wasting and underweight are 21% and , 8% and 6% respectively in Egyptian Demographic Health Survey 2014.

The main risk factors for growth restriction in children are maternal under nutrition during pregnancy, lack of exclusive breastfeeding, inappropriate complementary feeding and micronutrient intake and high prevalence of enteric infections. However, other environmental exposures may also play a role in growth restriction .

High concentrations of Arsenic, lead and cadmium in placenta are associated with poor fetal out come and low birth weight. Arsenic crosses the placenta causing suppression of insulin-Like Growth Factor 1.

When breastfeeding is exclusive, infants are unlikely to be exposed to Arsenic by other routes of exposure such as external foods, drinking water and foods made at home using Arsenic contaminated water.

Rational of the study. Improvement of under-five nutritional status is a global target. Although the exposure to arsenic has increased globally, it's impact on nutritional status has seldom been investigated.


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Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital
Estimated Study Start Date : June 2019
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : June 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Arsenic Malnutrition
Drug Information available for: Arsenic

Group/Cohort Intervention/treatment
malnourished under five children
children from 2 to 5 years with malnutrition
Diagnostic Test: arsenic exposure
analysis of hair samples for Arsenic using Agilent graphite tube atomizer 120

well nourished under five children
children from 2 to 5 years without malnutrition
Diagnostic Test: arsenic exposure
analysis of hair samples for Arsenic using Agilent graphite tube atomizer 120




Primary Outcome Measures :
  1. Chronic Arsenic Exposure of Under Five Children [ Time Frame: one year ]
    Hair samples collected from participating children will be analyzed for Arsenic using Agilent graphite tube atomizer (GTA) 120

  2. weight measurement [ Time Frame: one year ]
    weight in kilograms will be measured to all participating children

  3. height measurement [ Time Frame: one year ]
    height in meters will be measured to all participating children


Biospecimen Retention:   Samples Without DNA
Hair samples


Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 5 Years   (Child)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
under five children attending Assiut university Children Hospital
Criteria

Inclusion Criteria:

female children from 2 to 5 years

Exclusion Criteria:

Severely ill children other than severely malnourished.

  • Children with congenital anomaly.
  • Relatives.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03893721


Contacts
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Contact: Eman Morsy, professor 01006261140 ext 002 emanmma@yahoo.com
Contact: Medhat Araby, assis. prof. 01000032910 ext 002 medhatelaraby75@yahoo.com

Locations
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Egypt
Assiut University Not yet recruiting
Assiut, Egypt, 71111
Sponsors and Collaborators
Assiut University
Investigators
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Principal Investigator: Alyaa Abdelaal, demonstrator Assiut University

Additional Information:
Publications:
El-Badry AE-MA, Khalifa MM. Geochemical Assessment of Pollution at Manzala Lake, Egypt: Special Mention to Environmental and Health Effects of Arsenic, Selenium, Tin and Antimony. J Appl Sci [Internet]. 2017;17(2):72-80. Available from: http://dx.doi.org/10.3923/jas.2017.72.80
El-Badry AE-MA, Khalifa MM. The occurrence and distribution of high-arsenic, selenium, tin and antimony in bottom sediments of Burullus lagoon and its effects on human health, Egypt. J African Earth Sci [Internet]. 2017 Dec 1 [cited 2019 Feb 23];136:305-11. Available from: https://www.sciencedirect.com/science/article/pii/S1464343X17303175?via%3Dihub

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Responsible Party: alyaa abdelaal mohamed abdelaal, principle investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03893721     History of Changes
Other Study ID Numbers: 17100702
First Posted: March 28, 2019    Key Record Dates
Last Update Posted: March 28, 2019
Last Verified: March 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Arsenic Poisoning
Malnutrition
Child Nutrition Disorders
Poisoning
Nutrition Disorders
Chemically-Induced Disorders
Heavy Metal Poisoning, Nervous System
Neurotoxicity Syndromes
Nervous System Diseases