Supportive Measures in Treatment of Aluminum Phosphide Poisoning
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|ClinicalTrials.gov Identifier: NCT03879356|
Recruitment Status : Completed
First Posted : March 18, 2019
Last Update Posted : March 18, 2019
|Condition or disease||Intervention/treatment||Phase|
|Detection of Different Prognostic Factors and Their Relation With the Outcome Using New Protocol to Prove the Role of N-acetyl Cysteine and Adequate Supportive Measures in Aluminum Phosphide Poisoning||Drug: N-acetyl cysteine||Phase 4|
Aluminum phosphide poisoning is a major problem, accounting for many Emergency Unit visits and hospitalization, the incidence of aluminum phosphide poisoning increasing in the last few years.
ALP is used as pesticides for many years to protect grains in stores and during its transportation. The availability of these tablets and their low cost make it an easy and common method of suicide in our country with the increasing incidence of social and financial problems that face the youth.
In management, the main objective is to provide effective oxygenation, ventilation, and circulation until phosphine is excreted. All patients of severe ALP poisoning require continuous invasive hemodynamic monitoring and early resuscitation with fluid and vasoactive agents. N- acetylcysteine as an antioxidant and cytoprotective agent reduces myocardial oxidative injury and increase survival time. Magnesium sulfate helps in scavenging free radicals through glutathione (GSH) recovery hence is effective as a parenteral antioxidant in this poisoning as well as has been tried for its general membrane stabilizing effect in cardiac cells .
Death after 24 hours occurs usually owing to shock, cardiac arrhythmia, metabolic acidosis, and acute respiratory distress syndrome.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||44 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital|
|Actual Study Start Date :||January 1, 2016|
|Actual Primary Completion Date :||June 30, 2016|
|Actual Study Completion Date :||March 14, 2017|
Aluminum phosphide patients
effect of N-acetyl cysteine and supportive measures in outcome of aluminum phosphide poisoning cases
Drug: N-acetyl cysteine
effect of N-acetyl cysteine in Aluminum phosphide poisoning patients
- mortality rate comparison [ Time Frame: 3 days ]comparison of mortality rate using the New protocol and previous mortality rate from archive records
- hospital stay [ Time Frame: 3 days ]number of days the patient stayed at hospital