Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment (Neurofeedel)
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|ClinicalTrials.gov Identifier: NCT03855319|
Recruitment Status : Completed
First Posted : February 26, 2019
Last Update Posted : February 28, 2019
|Condition or disease||Intervention/treatment||Phase|
|Mild Cognitive Impairment||Behavioral: SMR neurofeedback training to MCI||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||no randomized, no controlled|
|Masking:||None (Open Label)|
|Official Title:||SMR/Theta Neurofeedback Training Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment: A Pilot Study|
|Actual Study Start Date :||December 15, 2016|
|Actual Primary Completion Date :||December 15, 2018|
|Actual Study Completion Date :||December 15, 2018|
Experimental: SMR neurofeedback training to MCI
A sensorimotor/theta neurofeedback training consisted of 20 individuals sessions, twice a week during 11 weeks maximum. For each subject, NF was planned and conducted by a neuropsychologist experienced in neurophysiology an neurofeedback. Each session lasted 1h10 minutes and was conducted as follows:
Behavioral: SMR neurofeedback training to MCI
The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.
- Rey Auditory Verbal Learning test [ Time Frame: Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up ]Assessment of verbal learning in episodic memory, evaluating the ability to encode, combine, store and long-term consolidation process.
- Relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands. [ Time Frame: Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up ]Electroencephalography was recorded and EEG power spectrum was calculated using the fast Fourier transform. The power spectral density was calculated to extract the relative power for each frequency band and estimated as a log-ratio.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03855319
|Principal Investigator:||anne-Sophie AR Rigaud, Professor||Study Principal Investigator|