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Trial record 1 of 1 for:    NCT03852225
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Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound

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ClinicalTrials.gov Identifier: NCT03852225
Recruitment Status : Recruiting
First Posted : February 25, 2019
Last Update Posted : February 25, 2019
Sponsor:
Collaborator:
Masaryk Hospital Usti nad Labem
Information provided by (Responsible Party):
Roman Skulec, Emergency Medical Service of the Central Bohemian Region, Czech Republic

Brief Summary:
Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR. Other potential marker of haemodynamic efficacy of CPR is direct measurement of the extent of induced compression of left ventricle (LV), right ventricle (RV) and inferior caval vein (IVC) by ultrasound. We plane to evaluate whether these ultrasound parameters correlate with EtCO2 levels during CPR for out-of-hospital cardiac arrest (OHCA) of non-traumatic origin.

Condition or disease Intervention/treatment
Cardiopulmonary Resuscitation Echocardiography Diagnostic Test: Intra-arrest echocardiography

Detailed Description:

Pre-hospital observational study will be realized in the setting of physician-based Emergency Medical System in the Czech republic. 20 patients resuscitated for OHCA of nontraumatic origin are planned to be included to the study. Transthoracic echocardiography will be performed from subcostal view during ongoing chest compressions in all of them and in the time of this investigation EtCO2 level will be recorded. This will be repeated three times during CPR in each patient if possible. Later on, maximal and minimal diameter of LV, RV and IVC will be obtained from the recorded loops and compression index (%) of LV (LVCI), RV (RVCI) and IVC (IVCCI) will be calculated as (maximal-minimal/maximal cavital diameter)x100. Correlations between EtCO2 and LVCI, RVCI and IVCI and CImax will be expressed as Spearman's correlation coefficient.

The results of the study will answer the question whether echocardiographic evaluation of compression of heart cavities during CPR reflect haemodynamic efficacy of CPR. If so, this study will be followed by an interventional clinical trial evaluating the effect of compression depth changes as a response to measured compression of the heart.

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Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Correlation Between End-tidal CO2 and Degree of Compression of Heart Cavities Measured by Transthoracic Ultrasound During Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
Actual Study Start Date : January 1, 2018
Estimated Primary Completion Date : March 15, 2019
Estimated Study Completion Date : March 31, 2019

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
OHCA patients
Patients resuscitated for out-of-hospital cardiac arrest of non-traumatic origin and investigated by intra-arrest echocardiography.
Diagnostic Test: Intra-arrest echocardiography
Intra-arrest echocardiography performed by portable ultrasound device during ongoing chest compressions.




Primary Outcome Measures :
  1. Correlation of EtCO2 level and compression index of left ventricle, right ventricle and inferior caval vein [ Time Frame: Participant will be repeatedly evaluated during cardiopulmonary resuscitation. Therefore, anticipated time frame the time interval will fluctuate from 5 minutes to 120 minutes ]
    Compression index of left ventricle, right ventricle and inferior caval vein measured by intra-arrest echocardiography and EtCO2 measured by side stream approach during cardiopulmonary resuscitation.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All consecutive patients meeting inclusion and exclusion criteria
Criteria

Inclusion Criteria:

  • Adult patient resuscitated for out-of-hospital cardiac arrest of non-traumatic origin.

Exclusion Criteria:

  • Technical unavailability of intra-arrest ultrasonography and capnography.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03852225


Locations
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Czechia
Emergency Medical Service of the Central Bohemian Region Recruiting
Kladno, Central Bohemian Region, Czechia
Contact: Roman Skulec, MD    00420 777 577 497    skulec@email.cz   
Contact: Jitka Callerova, MD    00420 777 844 471    callerova.hypotermie@email.cz   
Principal Investigator: Roman Skulec, MD, PhD         
Sub-Investigator: Petr Vojtisek, MD         
Sponsors and Collaborators
Emergency Medical Service of the Central Bohemian Region, Czech Republic
Masaryk Hospital Usti nad Labem

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Roman Skulec, Roman Skulec, MD, PhD, Emergency Medical Service of the Central Bohemian Region, Czech Republic
ClinicalTrials.gov Identifier: NCT03852225    
Other Study ID Numbers: 2018-02
First Posted: February 25, 2019    Key Record Dates
Last Update Posted: February 25, 2019
Last Verified: February 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No