Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound
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|ClinicalTrials.gov Identifier: NCT03852225|
Recruitment Status : Unknown
Verified February 2019 by Roman Skulec, Emergency Medical Service of the Central Bohemian Region, Czech Republic.
Recruitment status was: Recruiting
First Posted : February 25, 2019
Last Update Posted : February 25, 2019
|Condition or disease||Intervention/treatment|
|Cardiopulmonary Resuscitation Echocardiography||Diagnostic Test: Intra-arrest echocardiography|
Pre-hospital observational study will be realized in the setting of physician-based Emergency Medical System in the Czech republic. 20 patients resuscitated for OHCA of nontraumatic origin are planned to be included to the study. Transthoracic echocardiography will be performed from subcostal view during ongoing chest compressions in all of them and in the time of this investigation EtCO2 level will be recorded. This will be repeated three times during CPR in each patient if possible. Later on, maximal and minimal diameter of LV, RV and IVC will be obtained from the recorded loops and compression index (%) of LV (LVCI), RV (RVCI) and IVC (IVCCI) will be calculated as (maximal-minimal/maximal cavital diameter)x100. Correlations between EtCO2 and LVCI, RVCI and IVCI and CImax will be expressed as Spearman's correlation coefficient.
The results of the study will answer the question whether echocardiographic evaluation of compression of heart cavities during CPR reflect haemodynamic efficacy of CPR. If so, this study will be followed by an interventional clinical trial evaluating the effect of compression depth changes as a response to measured compression of the heart.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Correlation Between End-tidal CO2 and Degree of Compression of Heart Cavities Measured by Transthoracic Ultrasound During Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest|
|Actual Study Start Date :||January 1, 2018|
|Estimated Primary Completion Date :||March 15, 2019|
|Estimated Study Completion Date :||March 31, 2019|
Patients resuscitated for out-of-hospital cardiac arrest of non-traumatic origin and investigated by intra-arrest echocardiography.
Diagnostic Test: Intra-arrest echocardiography
Intra-arrest echocardiography performed by portable ultrasound device during ongoing chest compressions.
- Correlation of EtCO2 level and compression index of left ventricle, right ventricle and inferior caval vein [ Time Frame: Participant will be repeatedly evaluated during cardiopulmonary resuscitation. Therefore, anticipated time frame the time interval will fluctuate from 5 minutes to 120 minutes ]Compression index of left ventricle, right ventricle and inferior caval vein measured by intra-arrest echocardiography and EtCO2 measured by side stream approach during cardiopulmonary resuscitation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03852225
|Emergency Medical Service of the Central Bohemian Region||Recruiting|
|Kladno, Central Bohemian Region, Czechia|
|Contact: Roman Skulec, MD 00420 777 577 497 email@example.com|
|Contact: Jitka Callerova, MD 00420 777 844 471 firstname.lastname@example.org|
|Principal Investigator: Roman Skulec, MD, PhD|
|Sub-Investigator: Petr Vojtisek, MD|