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Trial record 40 of 76 for:    Long-chain fatty acids

Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)

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ClinicalTrials.gov Identifier: NCT03846908
Recruitment Status : Recruiting
First Posted : February 20, 2019
Last Update Posted : February 20, 2019
Sponsor:
Information provided by (Responsible Party):
Klaus Parhofer, Ludwig-Maximilians - University of Munich

Brief Summary:
Postprandial lipid metabolism will be evaluated in patients with hypertriglyceridemia and normo-lipidemic controls; different fats will be used (saturated fatty acids, mon-unsaturated fatty acids and medium chain fatty acids) for the oral fat challenge.

Condition or disease Intervention/treatment Phase
Hypertriglyceridemia Other: MCT Other: SFA Other: MUFA Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Diagnostic
Official Title: Postprandial Lipid Metabolism in Patients With Hypertriglyceridemia and Normo-lipidemic Controls: Medium Chain Fatty Acids (MCT) in Comparison to Long-chain, Saturated Fatty Acids (SFA) and Mono-unsaturated Fatty Acids (MUFA)
Actual Study Start Date : February 1, 2019
Estimated Primary Completion Date : January 2021
Estimated Study Completion Date : March 2021

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Triglycerides

Arm Intervention/treatment
Experimental: MCT
subjects start with MCT fat load
Other: MCT
patients will receive fat load with MCT

Other: SFA
patients will receive fat load with SFA

Other: MUFA
patients will receive fat load with MUFA

Experimental: SFA
subjects start with SFA fat load
Other: MCT
patients will receive fat load with MCT

Other: SFA
patients will receive fat load with SFA

Other: MUFA
patients will receive fat load with MUFA

Experimental: MUFA
subjects start with MUFA fat load
Other: MCT
patients will receive fat load with MCT

Other: SFA
patients will receive fat load with SFA

Other: MUFA
patients will receive fat load with MUFA




Primary Outcome Measures :
  1. postprandial hypertriglyceridemia [ Time Frame: 8 hours after fat meal ]
    area under the curve following oral fat load



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • hypertriglyceridemia (150 mg/dl-900 mg/dl)

Exclusion Criteria:

  • Lipid lowering drugs or indication for Lipid lowering drugs
  • LDL-cholesterol > 190 mg/dl
  • Diabetes mellitus

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03846908


Locations
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Germany
University Munich Recruiting
Munich, Germany, 81377
Contact: Klaus G Parhofer, MD    +49-89-7095 ext 3010    klaus.parhofer@med.uni-muenchen.de   
Contact: Elisa Waldmann, MD    +49-89-7095 ext 2262    elisa.waldmann@med.uni-muenchen.de   
Sponsors and Collaborators
Ludwig-Maximilians - University of Munich

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Responsible Party: Klaus Parhofer, Professor of Endocrinology and Metabolism, Ludwig-Maximilians - University of Munich
ClinicalTrials.gov Identifier: NCT03846908     History of Changes
Other Study ID Numbers: MCT-HTG
First Posted: February 20, 2019    Key Record Dates
Last Update Posted: February 20, 2019
Last Verified: February 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Hypertriglyceridemia
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases