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Sleep-dependent Learning in Aging

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ClinicalTrials.gov Identifier: NCT03840083
Recruitment Status : Recruiting
First Posted : February 15, 2019
Last Update Posted : March 13, 2019
Sponsor:
Information provided by (Responsible Party):
University of Massachusetts, Amherst

Brief Summary:
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.

Condition or disease Intervention/treatment Phase
Sleep Behavioral: Sleep Not Applicable

Detailed Description:

Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task.

Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning).

Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks.

Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake.

Exp 5: The investigators will examine the rate of decay of motor sequence learning.

Exp 6: The investigators will examine whether enhanced training ('overtraining') improves sleep-dependent memory consolidation for older adults.


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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 584 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging
Actual Study Start Date : July 15, 2018
Estimated Primary Completion Date : July 14, 2023
Estimated Study Completion Date : July 15, 2024

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Sleep
Individuals will either nap (Exps 1, 4) or have overnight sleep (Exps 2, 3, 5, 6)
Behavioral: Sleep
Participants will sleep (either a mid-day nap or normal overnight sleep)

No Intervention: Wake
Individuals will stay awake for the same amount of time as they slept in the sleep condition



Primary Outcome Measures :
  1. Change in memory accuracy for intervention compared to control [ Time Frame: 2 hours (Experiments 1,4) or 12 hours (Experiments 2,3,5,6) ]
    We will measure memory accuracy before the sleep/wake interval and subtract this from memory accuracy after the sleep wake interval. If sleep benefits memory then this value will be greater in the sleep condition compared to the wake condition.



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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 18-75 yrs
  • Healthy sleeper
  • No diagnosed sleep or neurodegenerative disorder

Exclusion Criteria:

  1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index >15; a Period-Limb Movement in Sleep index of >15/hr; sleep-onset latency > 45 min (indicative of insomnia); or sleep efficiency < 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
  2. Past diagnosis neurological illness or head injury
  3. Reported average sleep per night < 5 or > 9 hrs
  4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
  5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
  6. Daily caffeine intake of > 4 cups (coffee, tea, colas)
  7. Weekly alcohol intake of > 10 cups
  8. Pregnancy or < 12 months post-partum
  9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score > 25
  10. Abnormal sleep (e.g., shift work, travel across >2 time zones within the past 3 months).
  11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
  12. Score indicative of cognitive dysfunction (subtest scores < 40)
  13. Beck Depression Scale score indicative of depression (> 19).

Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:

  1. Left handed or ambidextrous
  2. Claustrophobia
  3. Presence of metal (thoroughly screened via questionnaire and metal detector)
  4. Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03840083


Locations
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United States, Massachusetts
University of Massachusetts Recruiting
Amherst, Massachusetts, United States, 01003
Contact: Mary Emma Searles    413-545-4831    msearles@umass.edu   
Sponsors and Collaborators
University of Massachusetts, Amherst

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Responsible Party: University of Massachusetts, Amherst
ClinicalTrials.gov Identifier: NCT03840083     History of Changes
Other Study ID Numbers: 2017-4290
First Posted: February 15, 2019    Key Record Dates
Last Update Posted: March 13, 2019
Last Verified: March 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No