Sleep-dependent Learning in Aging
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|ClinicalTrials.gov Identifier: NCT03840083|
Recruitment Status : Recruiting
First Posted : February 15, 2019
Last Update Posted : March 13, 2019
|Condition or disease||Intervention/treatment||Phase|
|Sleep||Behavioral: Sleep||Not Applicable|
Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task.
Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning).
Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks.
Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake.
Exp 5: The investigators will examine the rate of decay of motor sequence learning.
Exp 6: The investigators will examine whether enhanced training ('overtraining') improves sleep-dependent memory consolidation for older adults.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||584 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging|
|Actual Study Start Date :||July 15, 2018|
|Estimated Primary Completion Date :||July 14, 2023|
|Estimated Study Completion Date :||July 15, 2024|
Individuals will either nap (Exps 1, 4) or have overnight sleep (Exps 2, 3, 5, 6)
Participants will sleep (either a mid-day nap or normal overnight sleep)
No Intervention: Wake
Individuals will stay awake for the same amount of time as they slept in the sleep condition
- Change in memory accuracy for intervention compared to control [ Time Frame: 2 hours (Experiments 1,4) or 12 hours (Experiments 2,3,5,6) ]We will measure memory accuracy before the sleep/wake interval and subtract this from memory accuracy after the sleep wake interval. If sleep benefits memory then this value will be greater in the sleep condition compared to the wake condition.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03840083
|United States, Massachusetts|
|University of Massachusetts||Recruiting|
|Amherst, Massachusetts, United States, 01003|
|Contact: Mary Emma Searles 413-545-4831 firstname.lastname@example.org|