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A Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma

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ClinicalTrials.gov Identifier: NCT03834584
Recruitment Status : Recruiting
First Posted : February 8, 2019
Last Update Posted : July 18, 2019
Sponsor:
Information provided by (Responsible Party):
Agios Pharmaceuticals, Inc.

Brief Summary:
This study will evaluate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of AG-636, an oral Dihydroorotate Dehydrogenase (DHODH) inhibitor, in subjects with advanced lymphoma.

Condition or disease Intervention/treatment Phase
Lymphoma Drug: AG-636 Phase 1

Detailed Description:
The purpose of this Phase 1, multicenter, open-label study is to determine the maximum tolerated dose (MTD) of AG-636 and characterize its dose-limiting toxicities (DLTs) when given by mouth to subjects with advanced lymphoma that is refractory to standard treatment. During the dose escalation part of the study successive cohorts of subjects will be treated with increasing doses of AG-636 in order to determine its maximum tolerated dose (MTD). Subsequently, in the dose expansion part of the study, additional subjects will be treated at the MTD in order to confirm that dose's safety, tolerability, PK and PD, and to provide an opportunity to detect anti-lymphoma activity. The dose expansion part of the study will support the selection of a dose for future clinical studies (a recommended Phase 2 dose [RP2D]).

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 54 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase 1 Study of AG-636 in the Treatment of Subjects With Advanced Lymphoma
Actual Study Start Date : May 24, 2019
Estimated Primary Completion Date : July 2021
Estimated Study Completion Date : July 2021

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lymphoma

Arm Intervention/treatment
Experimental: AG-636
AG-636 dosed orally.
Drug: AG-636
AG-636 will be administered orally intermittently in 28-day cycles.




Primary Outcome Measures :
  1. The frequency of dose limiting toxicities (DLTs) associated with AG-636 administration during the first cycle (first 28 days) of treatment. [ Time Frame: Up to 28 days, on average ]

Secondary Outcome Measures :
  1. Characterize the Safety and Tolerability of AG-636 (number of treatment-related Adverse Events and Serious Adverse Events) [ Time Frame: Up to 24 weeks, on average ]
    As determined by the number of treatment-related Adverse Events and Serious Adverse Events

  2. Characterize the Pharmacodynamics of AG-636 [ Time Frame: Up to 24 weeks, on average ]
    Measured by changes from baseline in circulating upstream metabolites

  3. Pharmacokinetics of AG-636 in plasma [ Time Frame: Up to 24 weeks, on average ]
    Determined by the plasma concentration versus time profile of AG-636

  4. Clinical activity of AG-636 in Lymphoma [ Time Frame: Up to 24 weeks, on average ]
    Assessed by either the Lugano criteria for lymphoma or the 2011 International Society for Cutaneous Lymphomas (ISCL)/United States Cutaneous Lymphoma Consortium (USCLC)/ European Organization for Research and Treatment of Cancer (EORTC) criteria for mycosis fungoides (MF)/Sézary syndrome (SS)



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Be ≥18 years of age.
  2. Have a pathologically confirmed diagnosis of a non-Hodgkin or Hodgkin lymphoma that has progressed in spite of prior treatment, and for whom additional effective (curative or life-prolonging) standard therapy is not available. The lymphomas included in this study must fall within one of the following 2017 World Health Organization categories:

    1. Mature B-cell neoplasms (excluding plasma cell neoplasms, heavy chain disease, and primary central nervous system [CNS] lymphoma)
    2. Mature T- and NK-cell neoplasms
    3. Hodgkin lymphomas
    4. Immunodeficiency-associated lymphoproliferative disorders
  3. In the case of subjects who have lymphoma for which high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT) is considered a standard curative therapy, eligibility for this study requires that the subject's disease has relapsed after HD-ASCT, that the subject is not eligible for HD-ASCT, or that the subject has refused HD-ASCT.
  4. Have disease that can be clinically evaluated for improvement or progression. In the dose expansion phase of the study, subjects must have disease that is measurable (as defined by either the Lugano criteria for lymphoma or the 2011 ISCL/USCLC/EORTC criteria for MF/SS).
  5. Have an Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
  6. Have an absolute neutrophil count (ANC) ≥1,000/uL.
  7. Have a platelet count ≥75,000/uL.
  8. Have a serum total bilirubin level ≤1.5×ULN (upper limit of normal) in the absence of Gilbert syndrome. Subjects with Gilbert syndrome must have a serum total bilirubin level ≤1.5× their baseline value.
  9. Have alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels ≤3.0×ULN, unless due to underlying hematologic malignancy. If ALT/AST elevations are determined to be due to involvement by the underlying hematologic malignancy, subjects must have ALT/AST levels <5.0× the ULN.(Note: There are no specific requirements for alkaline phosphatase [ALP].)
  10. Have a creatinine clearance (CrCl) ≥ 30 mL/min (either measured or estimated by the Cockcroft-Gault formula). (Cockcroft-Gault formula for estimated creatinine clearance [eCrCl]: eCrCl = [140 - Age] × Weight [kg] × [0.85 if Female] / [72 × serum creatinine (mg/dL)]).
  11. Be fully recovered from major surgery and from the acute toxic effects of prior chemotherapy and radiotherapy. Residual chronic toxicities of prior therapy, eg, alopecia, Grade ≤2 peripheral neuropathy, are allowed.
  12. If female with reproductive potential, must have a negative serum pregnancy test prior to the start of study therapy. Females of reproductive potential, as well as fertile men and their female partners of reproductive potential, must agree to use 2 effective forms of contraception.
  13. Able to understand and have provided written informed consent.

Exclusion Criteria:

  1. Have a primary central nervous system (CNS) lymphoma.
  2. Have lymphomatous involvement of the CNS that is symptomatic or requires therapy. However, subjects who have completed treatment for lymphoma involving the CNS and have no further evidence of disease in the CNS may be enrolled in this study.
  3. Have lymphoma that requires immediate cytoreductive therapy.
  4. Have low-grade lymphoma that does not meet conventional criteria for requiring treatment.
  5. Have impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of AG-636, including any unresolved nausea, vomiting, or diarrhea that is National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Grade >1.
  6. Are unable to abstain from food or liquids other than water for 2 hours before and 2 hours after each dose of AG-636.
  7. Have an active infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C.
  8. Have an active infection (bacterial, viral, or fungal) that cannot be controlled with treatment.
  9. Have had significant active cardiac disease within 6 months prior to the start of study treatment, including any of the following:

    1. New York Heart Association (NYHA) class III or IV congestive heart failure.
    2. Acute myocardial infarction or angina pectoris.
    3. Stroke.
    4. Uncontrolled cardiac arrhythmia (subjects with rate-controlled atrial fibrillation are not excluded).
  10. Have a heart rate-corrected QT interval using Fridericia's method (QTcF) >470 msec. Patients with bundle branch block and a QTcF >470 msec should be discussed with the Medical Monitor for potential inclusion.
  11. Have any other concurrent severe and/or uncontrolled concomitant medical condition that could compromise participation in the study (eg, clinically significant pulmonary disease, clinically significant neurologic disorder).
  12. Have received any systemic anticancer treatment or radiotherapy less than 2 weeks before the first dose of AG-636.
  13. Have received radioimmunotherapy less than 6 weeks before the first dose of AG-636.
  14. Have received treatment with an investigational small molecule <2 weeks before the first dose of AG-636.
  15. Are taking medications that are sensitive substrates of CYP2C8, and that cannot be discontinued prior to starting treatment with AG-636.
  16. Are taking medications that are sensitive substrates of either P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP), and that cannot be discontinued prior to starting treatment with AG-636.
  17. Are pregnant or breastfeeding.
  18. Have any other medical or psychological condition deemed by the Investigator to be likely to interfere with the subject's ability to give informed consent or participate in the study.
  19. Have concurrent malignancy other than lymphoma; subjects must have been free of other malignancies for ≥1 year before the start of study treatment. However, subjects with the following history/concurrent conditions are allowed:

    1. Basal or squamous cell carcinoma of the skin
    2. Carcinoma in situ of the cervix
    3. Carcinoma in situ of the breast
    4. Incidental histologic finding of prostate cancer.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03834584


Contacts
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Contact: Medical Affairs Agios Pharmaceuticals, Inc. 1-833-228-8474 medinfo@agios.com

Locations
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United States, Connecticut
Yale Cancer Center Recruiting
New Haven, Connecticut, United States, 06519
Contact: Laura Leary, CCRC    203-737-8884      
Principal Investigator: Scott Huntington, MD         
United States, Florida
Moffitt Cancer Center Recruiting
Tampa, Florida, United States, 33612
Contact: Natalie Miller    813-745-2591    Natalie.Miller@Moffitt.org   
Principal Investigator: Bijal Shah, MD         
United States, Nebraska
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Susan Blumel, RN    402-559-9183    sblumel@unmc.edu   
Principal Investigator: Avyakta Kallam, M.D.         
United States, New York
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Rhea Boxill       boxillr@mskcc.org   
Principal Investigator: Gottfried von Keudell, MD         
United States, Washington
Seattle Cancer Care Alliance Recruiting
Seattle, Washington, United States, 98109
Contact: Karolyn Morris       kmorri@seattlecca.org   
Principal Investigator: Ajay Gopal, MD         
Sponsors and Collaborators
Agios Pharmaceuticals, Inc.

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Responsible Party: Agios Pharmaceuticals, Inc.
ClinicalTrials.gov Identifier: NCT03834584     History of Changes
Other Study ID Numbers: AG636-C-001
First Posted: February 8, 2019    Key Record Dates
Last Update Posted: July 18, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Agios Pharmaceuticals, Inc.:
Lymphoma
DHODH
Hodgkins Lymphoma
Non-Hodgkins Lymphoma
T-Cell Lymphoma

Additional relevant MeSH terms:
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Lymphoma
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases