Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD) ((AU-ROOAD))
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|ClinicalTrials.gov Identifier: NCT03824197|
Recruitment Status : Active, not recruiting
First Posted : January 31, 2019
Last Update Posted : July 8, 2020
Until now there is no medical treatment and/or intervention that can slow, stop or reverse the underlying neurodegenerative of Alzheimer's disease (AD). The goal of this study is to demonstrate "Oleocanthal rich-extra-virgin olive oil (EVOO) consumption stops or delay mild cognitive impairment conversion to AD by restoring the blood-brain barrier (BBB) function in humans".
- Evaluate effect of EVOO on the brain function by functional MRI (fMRI) imaging, and BBB function by dynamic contrast-enhanced MRI (DCE-MRI).
- Evaluate effect of EVOO on cognitive function and on selected biomarkers
|Condition or disease||Intervention/treatment||Phase|
|Alzheimer Disease Cerebral Amyloid Angiopathy||Other: EVOO Other: OO||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Care Provider)|
|Official Title:||Extra-virgin Olive Oil Prevents Mild Cognitive Impairment Conversion to Alzheimer's Disease|
|Actual Study Start Date :||May 7, 2019|
|Estimated Primary Completion Date :||December 8, 2020|
|Estimated Study Completion Date :||December 31, 2020|
Extra-virgin olive oil rich with oleocanthal and other phenolic compounds that will be added to daily diet
Extra-virgin olive oil that is rich with oleocanthal and other phenols.
Other Name: OC-rich EVOO
Olive oil with low phenolic content that will be added to daily diet
Olive oil low in oleocanthal and other phenols.
Other Name: Olive oil
- Effect of olive oil on the BBB intactness [ Time Frame: 6 months ]Will be evaluated by DCE-MRI
- Effect of olive oil on the brain activity [ Time Frame: 6 months ]Will be evaluated by fMRI
- Cognitive function [ Time Frame: 6 months ]A battery of cognitive tasks to assess memory
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03824197
|United States, Alabama|
|Auburn, Alabama, United States, 36849|
|Principal Investigator:||Amal Kaddoumi, PhD||Auburn University|