Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card
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This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard culture-based detection.
Condition or disease
This environmental surveillance tool will also include antimicrobial resistance (AMR) genes to describe resistome profile in environmental samples and to better inform us of the potential risks of exposure to these environments
Polymerase Chain Reaction (PCR) detection of poliovirus, enteric pathogens and antimicrobial resistance genes from environmental samples [ Time Frame: through study completion, an average of 1 year ]
Evaluate performance of the TaqMan Array Card (TAC) on environmental samples (sewage samples) collected in urban slum area of Mirpur. The primary purpose will be to use TAC to detect and monitor Sabin 1 and 3 polio viruses post SIA.
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Layout table for eligibility information
Ages Eligible for Study:
up to 4 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The investigators will conduct a Supplementary Immunization Activity (SIA) using bivalent oral polio vaccine (bOPV) and administer bOPV to at least 70% of all children under the age of 5 in the participating wards in the urban slums of Mirpur, Dhaka
birth-4 years of age
reside in selected urban slums of Mirpur Dhaka, Bangladesh