A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning (O-15 Water)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03806751|
Recruitment Status : Not yet recruiting
First Posted : January 16, 2019
Last Update Posted : November 15, 2019
|Condition or disease||Intervention/treatment||Phase|
|Validation of a New Noninvasive Method to Obtain the Arterial Input Function (AIF) Directly by PET Imaging||Drug: [O-15]Water Drug: Acetazolamide||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||6 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Healthy volunteers|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning|
|Estimated Study Start Date :||December 31, 2020|
|Estimated Primary Completion Date :||January 1, 2022|
|Estimated Study Completion Date :||January 1, 2022|
Experimental: [O-15]water PET/MRI
Volunteers will have two brain PET/MRI scans; first scan after injection of [O-15]water; second scan after injection of 1 gram of acetazolamide followed by injection of [O-15]water.
All study participants with undergo brain imaging with [O-15]water-PET/MRI without and with administration of the carbonic anhydrase inhibitor acetazolamide. The PET tracer will be used to measure regional cerebral perfusion, and the administration of acetazolamide will lead to increased cerebral perfusion compared to baseline cerebral perfusion.
The administration of acetazolamide will lead to increased cerebral perfusion compared to baseline cerebral perfusion.
Other Name: Diamox
- Comparison of arterial sampling to non-invasive methods to measure regional cerebral blood flow using [O-15]water-PET/MRI [ Time Frame: 3 years ]Measurements of regional cerebral blood flow with [O-15]water-PET/MRI using arterial sampling versus non-invasive image-based input function estimates will be compared.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03806751
|Contact: Jonathan McConathy, MD, PhDemail@example.com|
|Contact: April Riddle, RTfirstname.lastname@example.org|
|United States, Alabama|
|The Kirklin Clinic|
|Birmingham, Alabama, United States, 35249|
|UAB Advanced Imaging Facility|
|Birmingham, Alabama, United States, 35294|